Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Exp Biol Med (Maywood). 2024 Jul 22;249:10196. doi: 10.3389/ebm.2024.10196. eCollection 2024.
Observational studies have linked autoimmune diseases (ADs) with rhinosinusitis (RS) manifestations. To establish a causal relationship between ADs and RS, and to explore the potential mediating role of inflammatory mediators between ADs and RS, we utilized Mendelian randomization (MR) analysis. Using a two-sample MR methodology, we examined the causality between multiple sclerosis (MS), rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriasis (PsO), type 1 diabetes (T1D), Sjogren's syndrome (SS), celiac disease (CeD), Crohn's disease (CD), hypothyroidism (HT), Graves' disease (GD), and Hashimoto's thyroiditis and their association with chronic and acute rhinosinusitis (CRS and ARS, respectively).To achieve this, we employed three distinct MR techniques: inverse variance weighting (IVW), MR-Egger, and the weighted median method. Our analysis also included a variety of sensitivity assessments, such as Cochran's Q test, leave-one-out analysis, MR-Egger intercept, and MR-PRESSO, to ensure the robustness of our findings. Additionally, the study explored the role of inflammation proteins as a mediator in these relationships through a comprehensive two-step MR analysis. Among the ADs, MS, RA, T1D, CeD, and HT were determined as risk factors for CRS. Only CeD exhibited a causal relationship with ARS. Subsequent analyses identified interleukin-10 (IL-10) as a potential mediator for the association of MS, RA and HT with CRS, respectively., while C-X-C motif chemokine 10 levels (CXCL10) and T-cell surface glycoprotein CD6 isoform levels (CD6) were found to influence HT's effect on CRS. Our findings demonstrate a causative link between specific autoimmune diseases and rhinosinusitis, highlighting IL-10, CXCL10, and CD6 as potential mediators in this association.
观察性研究将自身免疫性疾病 (AD) 与鼻-鼻窦炎 (RS) 表现联系起来。为了确定 AD 与 RS 之间的因果关系，并探讨 AD 与 RS 之间炎症介质的潜在介导作用，我们利用了孟德尔随机化 (MR) 分析。使用两样本 MR 方法，我们检查了多发性硬化症 (MS)、类风湿关节炎 (RA)、强直性脊柱炎 (AS)、银屑病 (PsO)、1 型糖尿病 (T1D)、干燥综合征 (SS)、乳糜泻 (CeD)、克罗恩病 (CD)、甲状腺功能减退症 (HT)、格雷夫斯病 (GD) 和桥本甲状腺炎与慢性和急性鼻-鼻窦炎 (CRS 和 ARS，分别）之间的因果关系。为了实现这一目标，我们采用了三种不同的 MR 技术：逆方差加权 (IVW)、MR-Egger 和加权中位数法。我们的分析还包括各种敏感性评估，如 Cochrane's Q 检验、逐一剔除分析、MR-Egger 截距和 MR-PRESSO，以确保我们发现的稳健性。此外，该研究还通过全面的两步 MR 分析探索了炎症蛋白作为这些关系中介的作用。在 AD 中，MS、RA、T1D、CeD 和 HT 被确定为 CRS 的危险因素。只有 CeD 与 ARS 存在因果关系。随后的分析确定白细胞介素-10 (IL-10) 分别是 MS、RA 和 HT 与 CRS 相关的潜在中介物，而 C-X-C 基序趋化因子 10 水平 (CXCL10) 和 T 细胞表面糖蛋白 CD6 同工型水平 (CD6) 被发现影响 HT 对 CRS 的影响。我们的研究结果表明，特定的自身免疫性疾病与鼻-鼻窦炎之间存在因果关系，强调了 IL-10、CXCL10 和 CD6 作为该关联的潜在中介物。
