Health and Rehabilitation College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
School of Preclinical Medicine, Chengdu University, Chengdu, China.
Front Immunol. 2023 Sep 12;14:1238673. doi: 10.3389/fimmu.2023.1238673. eCollection 2023.
Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately linked to innate and adaptive immunity. A number of studies have demonstrated that a variety of immune cells and cytokines that play a vital role in mediating inflammation in CRS are also involved in remodeling of the nasal mucosa and the cells as well as different cytokines involved in remodeling in CRS are also able to exert some influence on inflammation, even though the exact relationship between inflammation and remodeling in CRS has not yet been fully elucidated. In this review, the potential role of immune cells and cytokines in regulating inflammation and remodeling of CRS mucosa has been described, starting with the immune cells and cytokines that act together in inflammation and remodeling. The goal is to aid researchers in understanding intimate connection between inflammation and remodeling of CRS and to offer novel ideas for future research.
慢性鼻-鼻窦炎（CRS）是一种常见的临床病症，其特征为持续性的黏膜炎症和组织重塑，其发病机制复杂，与先天免疫和适应性免疫密切相关。大量研究表明，多种免疫细胞和细胞因子在介导 CRS 炎症中发挥重要作用，同时也参与鼻黏膜和细胞重塑，不同细胞因子在 CRS 重塑中也能对炎症产生一定影响，尽管 CRS 中炎症和重塑的确切关系尚未完全阐明。在这篇综述中，描述了免疫细胞和细胞因子在调节 CRS 黏膜炎症和重塑中的潜在作用，首先描述了共同作用于炎症和重塑的免疫细胞和细胞因子。目的是帮助研究人员了解 CRS 炎症和重塑之间的密切关系，并为未来的研究提供新的思路。
