Kay M C, McCrary J A
Am J Ophthalmol. 1979 Dec;88(6):1087-90. doi: 10.1016/0002-9394(79)90421-5.
A 12-year-old man had a sudden onset of multiple cranial nerve palsies after treatment for a necrotizing lesion of the soft palate two years previously. It was thought that neurologic signs were secondary to extension of the local disease and radiation therapy to the base of the brain was begun. The patient died shortly thereafter. A diffuse atypical histiocytic lymphoma involving multiple cranial nerves, lumbosacral nerves, orbital muscles, and other organs was found on autopsy. Initial nasopharyngeal biopsy and autopsy findings were compatible with midline malignant reticulosis, a malignant lesion of the upper airway sometimes associated with metastasis. Our case is the first reported autopsy-documented case, to the best of our knowledge, of metastatic involvement of the cranial nerves in midline malignant reticulosis.
一名12岁男性在两年前因软腭坏死性病变接受治疗后突然出现多发性颅神经麻痹。当时认为神经症状是局部疾病扩展的继发表现，遂开始对脑底部进行放射治疗。此后不久患者死亡。尸检发现弥漫性非典型组织细胞淋巴瘤累及多条颅神经、腰骶神经、眼眶肌肉和其他器官。最初的鼻咽活检和尸检结果符合中线恶性网状细胞增多症，这是一种上呼吸道的恶性病变，有时伴有转移。据我们所知，我们的病例是首例经尸检证实的中线恶性网状细胞增多症累及颅神经转移的病例。
