Nisbett Khalin E
Graduate Program in Neuroscience, Graduate College, University of Illinois Chicago, Chicago, IL, 60607, USA.
Stress & Addiction Neuroscience Unit, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, 21224, USA.
Compr Psychoneuroendocrinol. 2024 Jun 26;19:100244. doi: 10.1016/j.cpnec.2024.100244. eCollection 2024 Aug.
This narrative review summarizes the early life of the author, Khalin E. Nisbett, and highlights the factors that led to her career in research and her development of two novel research hypotheses: the u-opioid and ytocin system nteraction (MOXI) hypothesis and u-Opioid receptor antagonist and ytocin receptor gonist n ombination (MOXAIC) treatment hypothesis. Notably, Nisbett's career began in the era after countless studies demonstrated that oxytocin is not just a female neurotransmitter and not just a female reproductive hormone, an era in which researchers are exploring the role of oxytocin in emotion regulation, social interaction, and cognitive processing across both sexes. As such, the previously held perspective that oxytocin is "just a female hormone" did not impede Nisbett's ideas. Intrigued by science, emotion regulation, and social interaction, she began to explore the role of oxytocin and opioids in emotion regulation. On the heels of earlier theories, such as the Tend-and-Befriend theory and Opioid Theory of Social Attachment, she began to develop the MOXI hypothesis, which postulates that the μ-opioid receptor and oxytocin systems interact to mediate social interaction and emotion regulation. In this narrative review, Nisbett summarizes two studies that explored (i) the role of oxytocin in anxiety- and depression-like behavior and (ii) the effect of opioid receptor blockade on the anxiolytic-like effect of oxytocin, which led to a revision of the MOXI hypothesis and postulation of the Mu-Opioid receptor antagonist and OXytocin receptor Agonist In Combination (MOXAIC) treatment hypothesis. Nisbett also discusses several limitations of these hypotheses and her current research interests and aspirations.
这篇叙述性综述总结了作者卡林·E·尼斯比特的早年经历，并强调了促使她投身研究事业的因素，以及她提出的两个新颖的研究假设：μ-阿片肽与催产素系统相互作用（MOXI）假说和μ-阿片受体拮抗剂与催产素受体激动剂联合（MOXAIC）治疗假说。值得注意的是，尼斯比特的职业生涯始于无数研究表明催产素不仅是一种女性神经递质，也不仅是一种女性生殖激素的时代，在这个时代，研究人员正在探索催产素在情绪调节、社交互动和两性认知加工中的作用。因此，先前认为催产素“只是一种女性激素”的观点并没有阻碍尼斯比特的想法。受科学、情绪调节和社交互动的吸引，她开始探索催产素和阿片肽在情绪调节中的作用。在早期理论，如“tend-and-befriend”理论和社会依恋的阿片肽理论的基础上，她开始提出MOXI假说，该假说假定μ-阿片受体和催产素系统相互作用以介导社交互动和情绪调节。在这篇叙述性综述中，尼斯比特总结了两项研究，这两项研究探讨了（i）催产素在焦虑样和抑郁样行为中的作用，以及（ii）阿片受体阻断对催产素抗焦虑样作用的影响，这导致了对MOXI假说的修订以及μ-阿片受体拮抗剂与催产素受体激动剂联合（MOXAIC）治疗假说的提出。尼斯比特还讨论了这些假说的几个局限性以及她目前的研究兴趣和抱负。
