• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种通过基于自动展示筛选鉴定出的用于含N-甲基-D-天冬氨酸受体的GluN2A的新型荧光标记化合物。

A novel fluorescent labeling compound for GluN2A containing -methyl-d-aspartate receptors identified by autodisplay-based screening.

作者信息

Dombovski Alexander, Steigerwald Ruben, Ritter Nadine, Disse Paul, Goerges Gunnar, Osthues Jana, Aymanns Isabel, Dilkaute Carina, Schreiber Julian, Düfer Martina, Seebohm Guiscard, Wünsch Bernhard, Jose Joachim

机构信息

University of Münster, Institute of Pharmaceutical and Medicinal Chemistry, Pharmacampus, 48149, Münster, Germany.

University of Münster, GRK 2515, Chemical Biology of Ion Channels (Chembion), 48149, Münster, Germany.

出版信息

J Pharm Anal. 2024 Jul;14(7):100945. doi: 10.1016/j.jpha.2024.01.013. Epub 2024 Feb 5.

DOI:10.1016/j.jpha.2024.01.013
PMID:39104865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11298907/
Abstract

Image 1.

摘要

图1。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/14b08ae72ae4/figs11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/2a43bd84e906/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/77c73716779d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/8729ab85ff86/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/6f9eaf0b64df/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/94b3b7ed6ad3/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/62f7297f3c27/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/ea462b12df8c/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/5738c977e9c3/figs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/ab719800c23c/figs7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/3c8d6db0c157/figs8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/15e470adf244/figs9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/654d43068b7d/figs10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/14b08ae72ae4/figs11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/2a43bd84e906/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/77c73716779d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/8729ab85ff86/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/6f9eaf0b64df/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/94b3b7ed6ad3/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/62f7297f3c27/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/ea462b12df8c/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/5738c977e9c3/figs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/ab719800c23c/figs7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/3c8d6db0c157/figs8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/15e470adf244/figs9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/654d43068b7d/figs10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab86/11298907/14b08ae72ae4/figs11.jpg

相似文献

1
A novel fluorescent labeling compound for GluN2A containing -methyl-d-aspartate receptors identified by autodisplay-based screening.一种通过基于自动展示筛选鉴定出的用于含N-甲基-D-天冬氨酸受体的GluN2A的新型荧光标记化合物。
J Pharm Anal. 2024 Jul;14(7):100945. doi: 10.1016/j.jpha.2024.01.013. Epub 2024 Feb 5.
2
Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment.6-甲基吡啶-2-酮衍生物作为新型强效GluN2A正变构调节剂用于治疗认知障碍的设计与合成
Bioorg Med Chem. 2023 Feb 1;79:117150. doi: 10.1016/j.bmc.2022.117150. Epub 2022 Dec 24.
3
Opportunities for Precision Treatment of and Gain-of-Function Variants in Triheteromeric N-Methyl-D-Aspartate Receptors.三聚体 N-甲基-D-天冬氨酸受体功能获得性变异的精准治疗机会。
J Pharmacol Exp Ther. 2022 Apr;381(1):54-66. doi: 10.1124/jpet.121.001000. Epub 2022 Feb 2.
4
Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity.发现吡唑并[1,5-a]吡嗪-4-酮类化合物作为强效和脑穿透性的 GluN2A 选择性正变构调节剂，降低 AMPA 受体结合活性。
Bioorg Med Chem. 2022 Feb 15;56:116576. doi: 10.1016/j.bmc.2021.116576. Epub 2021 Dec 16.
5
MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit.MPX - 004和MPX - 007：研究含GluN2A亚基的NMDA受体生理学的新型药理学工具。
PLoS One. 2016 Feb 1;11(2):e0148129. doi: 10.1371/journal.pone.0148129. eCollection 2016.
6
Progresses in GluN2A-containing NMDA Receptors and their Selective Regulators.含 GluN2A 的 N-甲基-D-天冬氨酸受体及其选择性调节剂的研究进展
Cell Mol Neurobiol. 2023 Jan;43(1):139-153. doi: 10.1007/s10571-021-01185-1. Epub 2022 Jan 3.
7
Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits.含嵌合 GluN2A/GluN2D 亚基的 N-甲基-D-天冬氨酸受体的单通道特性。
Biochem Soc Trans. 2009 Dec;37(Pt 6):1347-54. doi: 10.1042/BST0371347.
8
Systematic variation of the benzenesulfonamide part of the GluN2A selective NMDA receptor antagonist TCN-201.谷氨酸N2A亚基选择性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂TCN-201的苯磺酰胺部分的系统变异
Eur J Med Chem. 2017 Mar 31;129:124-134. doi: 10.1016/j.ejmech.2017.02.018. Epub 2017 Feb 14.
9
Cysteine substitution of transmembrane domain amino acids alters the ethanol inhibition of GluN1/GluN2A N-methyl-D-aspartate receptors.半胱氨酸取代跨膜域氨基酸会改变谷氨酸 N-甲基-D-天冬氨酸受体 GluN1/GluN2A 对乙醇的抑制作用。
J Pharmacol Exp Ther. 2015 Apr;353(1):91-101. doi: 10.1124/jpet.114.222034. Epub 2015 Jan 29.
10
Pharmacology of triheteromeric N-Methyl-D-Aspartate Receptors.三聚体 N-甲基-D-天冬氨酸受体的药理学
Neurosci Lett. 2016 Mar 23;617:240-6. doi: 10.1016/j.neulet.2016.02.032. Epub 2016 Feb 23.

本文引用的文献

1
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.谷氨酸受体离子通道的结构、功能和药理学。
Pharmacol Rev. 2021 Oct;73(4):298-487. doi: 10.1124/pharmrev.120.000131.
2
Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.含GluN2A的N-甲基-D-天冬氨酸受体负变构调节的结构基础
Neuron. 2016 Sep 21;91(6):1316-1329. doi: 10.1016/j.neuron.2016.08.014. Epub 2016 Sep 8.
3
Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.NMDA 受体甘氨酸结合的亚基选择性变构抑制。
J Neurosci. 2012 May 2;32(18):6197-208. doi: 10.1523/JNEUROSCI.5757-11.2012.
4
The autodisplay story, from discovery to biotechnical and biomedical applications.自展示技术的历程：从发现到生物技术与生物医学应用
Microbiol Mol Biol Rev. 2007 Dec;71(4):600-19. doi: 10.1128/MMBR.00011-07.
5
Subunit arrangement and function in NMDA receptors.NMDA受体的亚基排列与功能
Nature. 2005 Nov 10;438(7065):185-92. doi: 10.1038/nature04089.