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囊性纤维化患者对葡萄糖负荷的胰岛素和C肽反应。

Insulin and C-peptide responses to glucose load in cystic fibrosis.

作者信息

Mohan V, Alagappan V, Snehalatha C, Ramachandran A, Thiruvengadam K V, Viswanathan M

出版信息

Diabete Metab. 1985 Dec;11(6):376-9.

PMID:3910489
Abstract

Immunoreactive Insulin and C-peptide responses to glucose load were estimated in patients with cystic fibrosis and in controls. Both insulin and C-peptide responses were low in cystic fibrosis patients and the changes were more marked in those with glucose intolerance. There appears to be true pancreatic hyposecretion of insulin in patients with cystic fibrosis whereas the peripheral sensitivity of insulin seems to be normal or enhanced.

摘要

对囊性纤维化患者和对照组进行了葡萄糖负荷下免疫反应性胰岛素和C肽反应的评估。囊性纤维化患者的胰岛素和C肽反应均较低,且在糖耐量异常的患者中变化更为明显。囊性纤维化患者似乎存在真正的胰腺胰岛素分泌不足,而胰岛素的外周敏感性似乎正常或增强。

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Insulin and C-peptide responses to glucose load in cystic fibrosis.囊性纤维化患者对葡萄糖负荷的胰岛素和C肽反应。
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[Plasma glucose, insulin and C-peptide responses in normal subjects to 100, 75 and 50 grams of glucose load during glucose tolerance test].
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引用本文的文献

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Impaired counterregulatory responses to hypoglycaemia following oral glucose in adults with cystic fibrosis.成年囊性纤维化患者口服葡萄糖后低血糖的代偿反应受损。
Diabetologia. 2020 May;63(5):1055-1065. doi: 10.1007/s00125-020-05096-6. Epub 2020 Jan 29.
2
Reduced β-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose Tolerance.尽管葡萄糖耐量正常,但胰腺功能不全而非胰腺功能正常的囊性纤维化患者的β细胞分泌能力降低。
Diabetes. 2017 Jan;66(1):134-144. doi: 10.2337/db16-0394. Epub 2016 Aug 5.
3
Genetic dissection of diabetes: facing the giant.
糖尿病的基因剖析:直面巨人
Diabetes. 2013 Oct;62(10):3338-40. doi: 10.2337/db13-1154.
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Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress.囊性纤维化相关糖尿病:从囊性纤维化跨膜传导调节因子功能障碍到氧化应激
Clin Biochem Rev. 2009 Nov;30(4):153-77.
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Glycosylated haemoglobin and glucose intolerance in cystic fibrosis.囊性纤维化中的糖化血红蛋白与葡萄糖不耐受
Arch Dis Child. 1987 Aug;62(8):805-10. doi: 10.1136/adc.62.8.805.
6
Glucose tolerance in cystic fibrosis.囊性纤维化患者的葡萄糖耐量
Arch Dis Child. 1991 May;66(5):612-6. doi: 10.1136/adc.66.5.612.