重度抑郁症与功能性消化不良之间的因果关系：一项两样本孟德尔随机化研究。
Causality between major depressive disorder and functional dyspepsia: a two-sample Mendelian randomization study.
作者信息
Du Yaming, Wang Rui, Xu Xinzi, Wang Junli, Shao Wei, Chen Guohua
机构信息
Clinical College of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan City, China.
Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
出版信息
Front Neurol. 2024 Jul 22;15:1338153. doi: 10.3389/fneur.2024.1338153. eCollection 2024.
BACKGROUND
To investigate the causal relationship between major depression and functional dyspepsia using two-sample Mendelian randomization.
METHODS
Data for major depression and functional dyspepsia were obtained from genome-wide association studies. We selected Single Nucleotide Polymorphisms (SNPs) strongly associated with severe depression. Mendelian randomization analysis was conducted using methods such as Inverse-Variance Weighted (IVW), MR-Egger, and Weighted Median Estimator (WME). Sensitivity analysis was performed to assess the robustness of the results.
RESULTS
A total of 31 eligible SNPs were identified as instrumental variables for major depression. IVW analysis indicated a positive causal relationship between the two conditions ( = 0.328; SE = 0.137; = 0.017), suggesting that severe depression increases the risk of functional dyspepsia (OR = 1.389; 95% CI: 1.062-1.816). Sensitivity tests showed no evidence of heterogeneity or horizontal pleiotropy ( > 0.05).
CONCLUSION
MR analysis had shown that major depressive disorder is associated with an increased risk of functional dyspepsia.
背景
采用两样本孟德尔随机化方法研究重度抑郁症与功能性消化不良之间的因果关系。
方法
重度抑郁症和功能性消化不良的数据来自全基因组关联研究。我们选择了与重度抑郁症密切相关的单核苷酸多态性（SNP）。使用逆方差加权（IVW）、MR-Egger和加权中位数估计器（WME）等方法进行孟德尔随机化分析。进行敏感性分析以评估结果的稳健性。
结果
共鉴定出31个符合条件的SNP作为重度抑郁症的工具变量。IVW分析表明这两种情况之间存在正因果关系（β = 0.328；标准误 = 0.137；P = 0.017），表明重度抑郁症会增加功能性消化不良的风险（比值比 = 1.389；95%置信区间：1.062 - 1.816）。敏感性测试未显示异质性或水平多效性的证据（P > 0.05）。
结论
孟德尔随机化分析表明，重度抑郁症与功能性消化不良风险增加有关。
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