Yang Wendy, Jones Anastasia, Mahil Amreesh, Nahrwold Daniel
Department of Medical Education, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Department of Anesthesiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Case Rep Womens Health. 2024 Jul 10;43:e00635. doi: 10.1016/j.crwh.2024.e00635. eCollection 2024 Oct.
Gastrointestinal stromal tumors (GISTs) are neoplasms of neural cells in the gastrointestinal tract; they typically develop in older adults, with less than 10% of cases presenting among patients under the age of 40. This report describes the clinical course and management of a 28-year-old woman with a history of irritable bowel syndrome (IBS) who presented with acute upper abdominal pain. Surgical pathology confirmed a diagnosis of metastatic GIST. The patient underwent imatinib therapy and subsequent surgical tumor debulking. Postoperatively, she presented with acute appendicitis, for which she eventually required appendectomy, and she became pregnant approximately 1 year after the initial diagnosis. This case highlights several treatment challenges that may be encountered in young patients presenting with GIST.
胃肠道间质瘤（GISTs）是胃肠道神经细胞的肿瘤；它们通常发生于老年人，40岁以下患者中病例占比不到10%。本报告描述了一名有肠易激综合征（IBS）病史、出现急性上腹痛的28岁女性的临床病程及治疗情况。手术病理确诊为转移性GIST。该患者接受了伊马替尼治疗及随后的肿瘤减瘤手术。术后，她出现了急性阑尾炎，最终接受了阑尾切除术，并且在初次诊断后约1年怀孕。该病例凸显了年轻GIST患者可能遇到的几个治疗挑战。
