Faculty of Pharmacy, Department of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Medical University of Warsaw, Warsaw, Poland.
Food Addit Contam Part B Surveill. 2024 Dec;17(4):328-341. doi: 10.1080/19393210.2024.2382221. Epub 2024 Aug 6.
Dietary supplements are widely consumed. However, the lack of mandatory testing results in limited data on their quality, particularly in Eastern Europe. In this study, 21 legally registered and 9 illegal supplements, seized from an underground facility by the Polish Police, were examined. Contaminants were screened by utilising high-performance liquid chromatography coupled with untargeted mass spectrometry. The analysis identified 32 contaminants in the 30 dietary supplements examined. Untargeted analysis revealed a concerning issue: the intentional adulteration of both legal and illegal supplements with pharmacologically active substances that are prohibited in this category of products. This study indicated that many dietary supplements are of low quality due to deliberate adulteration or inadequate manufacturing conditions. The presence of unregistered or unapproved substances in these supplements poses serious health risks. Strong legal regulations are essential to address this issue effectively.
膳食补充剂广泛消费。然而，由于缺乏强制性检测，其质量的数据有限，尤其是在东欧。在这项研究中，从波兰警方取缔的地下窝点查获了 21 种合法注册和 9 种非法补充剂，并对其进行了检查。利用高效液相色谱结合非靶向质谱法对污染物进行了筛选。分析在 30 种被检测的膳食补充剂中发现了 32 种污染物。非靶向分析揭示了一个令人担忧的问题：合法和非法补充剂都被故意掺入了在这一类产品中被禁止的具有药理活性的物质。这项研究表明，由于故意掺假或制造条件不足，许多膳食补充剂的质量都很差。这些补充剂中存在未经注册或未经批准的物质，会带来严重的健康风险。必须有强有力的法律法规才能有效地解决这个问题。
