Department of Neuropathology, Neurology Center, St. Mary's Hospital, Kurume, Japan.
Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
Neuropathology. 2024 Dec;44(6):422-431. doi: 10.1111/neup.12999. Epub 2024 Aug 6.
N-myc downstream regulated gene 1 (NDRG1) is a member of the NDRG family, of which four members (NDRG1, NDRG2, NDRG3, and NDRG4) have been identified. NDRG1 is repressed by c-MYC and N-MYC proto-oncogenes. NDRG1 is translated into a 43 kDa protein that is associated with the regulation of cellular stress responses, proliferation, and differentiation. In this study, we aimed to clarify the relationship between progression of glioblastoma (GB) IDH-wildtype and NDRG1 expression in tumor cells. We assessed the expression of NDRG1 in 41 GBs using immunostaining and evaluated its prognostic significance. NDRG1 expression by GBs was evaluated using Histoscore, which showed high and low scores in 23 and 18 cases, respectively. NDRG1-positive cells were strongly expressed in Ki-67 labeled proliferating tumor cells and CD105 positive proliferating microvessels around the area of palisading necrosis. Statistical analyses showed lower survival rates in the high-score group than the low-score group (P < 0.01). This study indicated that overexpression of NDRG1 by GB reflects tumor angiogenesis and poor patient prognosis.
N- MYC 下游调节基因 1（NDRG1）是 NDRG 家族的成员之一，其中已经鉴定出四个成员（NDRG1、NDRG2、NDRG3 和 NDRG4）。NDRG1 受到 c-MYC 和 N-MYC 原癌基因的抑制。NDRG1 被翻译为 43kDa 的蛋白质，与细胞应激反应、增殖和分化的调节有关。在这项研究中，我们旨在阐明 IDH-野生型胶质母细胞瘤（GB）进展与肿瘤细胞中 NDRG1 表达之间的关系。我们使用免疫染色评估了 41 例 GB 中 NDRG1 的表达，并评估了其预后意义。使用 Histoscore 评估了 NDRG1 在 GB 中的表达，其中 23 例为高评分，18 例为低评分。NDRG1 阳性细胞在 Ki-67 标记的增殖肿瘤细胞和围绕栅栏状坏死区域的 CD105 阳性增殖微血管中强烈表达。统计分析显示，高评分组的生存率低于低评分组（P<0.01）。这项研究表明，GB 中 NDRG1 的过表达反映了肿瘤血管生成和患者预后不良。
