Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University for Technology & Information MTI, Cairo, 11571, Egypt.
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Future Med Chem. 2024 Aug 17;16(16):1685-1703. doi: 10.1080/17568919.2024.2379234. Epub 2024 Aug 6.
Cardiovascular diseases (CVDs) and cancer are the top two leading causes of death globally. Vasodilators are commonly used to treat various CVDs. In cancer treatment, targeted anticancer agents have been developed to minimize side effects compared with traditional chemotherapy. Many hypertension patients are more prone to cancer, a case known as reverse cardio-oncology. This leads to the search for drugs with dual activity or repurposing strategy to discover new therapeutic uses for known drugs. Recently, medicinal chemists have shown great interest in synthesizing pyridazinone derivatives due to their significant biological activities in tackling these critical health challenges. This review will concentrate on pyridazin-3(2)-one-containing compounds as vasodilators and anticancer agents, along with a brief overview of various methods for their synthesis.
心血管疾病（CVDs）和癌症是全球导致死亡的前两大原因。血管扩张剂常用于治疗各种 CVDs。在癌症治疗中，与传统化疗相比，已经开发出靶向抗癌药物以尽量减少副作用。许多高血压患者更容易患癌症，这种情况被称为反向心脏肿瘤学。这导致人们寻找具有双重活性或重新定位策略的药物，以发现已知药物的新治疗用途。最近，由于在应对这些重大健康挑战方面具有显著的生物活性，药物化学家对合成哒嗪酮衍生物表现出极大的兴趣。本综述将集中讨论含哒嗪-3(2)-酮的化合物作为血管扩张剂和抗癌剂，以及它们的各种合成方法的简要概述。
