Akbarzadeh Armin, Gerami Mohammad Hadi, Farrokhi Majid Reza, Shapoori Shima, Jafarinia Morteza
Department of Orthopedic Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mol Cell Biochem. 2025 Mar;480(3):1275-1286. doi: 10.1007/s11010-024-05082-1. Epub 2024 Aug 6.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammatory joint damage. Recent studies have focused on the significance of microRNAs (miRNAs) in the pathogenesis of RA. Mesenchymal stem cells (MSCs) have emerged as a potential therapeutic option for RA based on their regenerative and immunomodulatory properties. MSCs release extracellular vesicles (EVs) containing miRNAs that can modulate immune and inflammatory responses. This article provides a comprehensive overview of the current evidence on the existence of various MSCs-derived miRNAs involved in the pathophysiology, characterization, and treatment of RA. An overview of the miRNA profiles in MSC-EVs is provided, along with an examination of their impact on various cell types implicated in RA pathogenesis, including synovial fibroblasts, macrophages, and T cells. Furthermore, the therapeutic capability of MSC-EVs for miRNA-based therapies in RA is discussed. In total, this review can present an extensive view of the complex interaction between EVs and MSC-derived miRNAs in RA and thus suggest valuable strategies for developing new therapeutic approaches to target this debilitating disease.
类风湿性关节炎（RA）是一种以炎症性关节损伤为特征的慢性自身免疫性疾病。最近的研究集中在微小RNA（miRNA）在RA发病机制中的重要性。基于其再生和免疫调节特性，间充质干细胞（MSC）已成为RA的一种潜在治疗选择。MSC释放含有miRNA的细胞外囊泡（EV），这些miRNA可调节免疫和炎症反应。本文全面概述了目前关于参与RA病理生理学、特征和治疗的各种MSC衍生miRNA存在的证据。提供了MSC-EV中miRNA谱的概述，并研究了它们对RA发病机制中涉及的各种细胞类型的影响，包括滑膜成纤维细胞、巨噬细胞和T细胞。此外，还讨论了MSC-EV在基于miRNA的RA治疗中的治疗能力。总之，本综述可以广泛展示EV与MSC衍生的miRNA在RA中的复杂相互作用，从而为开发针对这种使人衰弱疾病的新治疗方法提出有价值的策略。
