Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Support Care Cancer. 2024 Aug 6;32(9):571. doi: 10.1007/s00520-024-08777-9.
To evaluate the oral health-related quality of life (OHRQoL) of individuals diagnosed with Fanconi anemia (FA).
A cross-sectional study was conducted with FA patients from two Brazilian referral centers. Participants underwent a complete dental, periodontal, and oral mucosa examination, as well as assessment of resting salivary flow. The short version of the Oral Health Impact Profile (OHIP-14) questionnaire was administered. Descriptive and bivariate analyses were performed, followed by multivariate analysis to examine the impact of independent variables on OHRQoL.
The study included 20 (57.1%) males and 15 (42.9%) females, with a mean age of 18.9 years. Oral leukoplakia (OL) was found in 18 individuals. The overall OHIP-14 score was 9.9 ± 10.5. Individuals aged ≥ 16 years had higher OHIP-14 scores, indicating worse OHRQoL for physical pain (p = 0.007), psychological discomfort (p = 0.001), physical disability (p = 0.03), psychological disability (p = 0.001), handicap (p = 0.004), and overall score (p = 0.007). Females reported more negative OHRQoL than males for physical pain (p = 0.02), psychological discomfort (p = 0.03), psychological disability (p = 0.009), and overall score (p = 0.02). Individuals with OL had an overall OHIP-14 score 1.83 times higher than those without OL (95% CI: 1.02-3.28; p = 0.04). Lower salivary flow correlated with higher overall OHIP-14 scores (95% CI: 0.14-0.84; p = 0.01).
This study represents the first attempt to evaluate OHRQoL in individuals with FA. The presence of OL and reduced salivary flow were identified as predictors of a negative impact on OHRQoL. It is imperative to integrate patients' quality of life in the clinical treatment protocols for the FA population.
评估范可尼贫血（FA）患者的口腔健康相关生活质量（OHRQoL）。
本研究为巴西两家转诊中心的 FA 患者进行了一项横断面研究。参与者接受了全面的口腔、牙周和口腔黏膜检查，并评估了静止唾液流量。采用口腔健康影响程度量表（OHIP-14）的短版进行评估。进行了描述性和双变量分析，随后进行多变量分析，以检查独立变量对 OHRQoL 的影响。
研究纳入 20 名男性（57.1%）和 15 名女性（42.9%），平均年龄为 18.9 岁。18 名个体存在口腔白斑（OL）。OHIP-14 总分 9.9±10.5。年龄≥16 岁的个体 OHIP-14 评分较高，表明他们在身体疼痛（p=0.007）、心理不适（p=0.001）、身体残疾（p=0.03）、心理残疾（p=0.001）、障碍（p=0.004）和总分（p=0.007）方面的 OHRQoL 更差。女性在身体疼痛（p=0.02）、心理不适（p=0.03）、心理残疾（p=0.009）和总分（p=0.02）方面报告的 OHRQoL 比男性更差。患有 OL 的个体的 OHIP-14 总分比没有 OL 的个体高 1.83 倍（95%CI：1.02-3.28；p=0.04）。唾液流量较低与较高的 OHIP-14 总分相关（95%CI：0.14-0.84；p=0.01）。
本研究首次尝试评估 FA 患者的 OHRQoL。OL 的存在和唾液流量减少被确定为对 OHRQoL 产生负面影响的预测因素。在 FA 人群的临床治疗方案中，必须将患者的生活质量纳入其中。
