Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, China.
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China.
J Agric Food Chem. 2024 Aug 21;72(33):18423-18433. doi: 10.1021/acs.jafc.4c04312. Epub 2024 Aug 6.
Natural products are a valuable resource for the discovery of novel crop protection agents. A series of γ-butyrolactone derivatives, derived from the simplification of podophyllotoxin's structure, were synthesized and assessed for their efficacy against tobacco mosaic virus (TMV). Several derivatives exhibited notable antiviral properties, with compound demonstrating the most potent anti-TMV activity. At 500 μg/mL, compound achieved an inactivation effect of 87.8%, a protective effect of 71.7%, and a curative effect of 67.7%, surpassing the effectiveness of the commercial plant virucides and . Notably, the -diastereomer (-) exhibited superior antiviral activity compared to the -diastereomer (-). Mechanistic studies revealed that - could bind to the TMV coat protein and interfere with the self-assembly process of TMV particles. These findings indicate that compound , with its simple chemical structure, could be a potential candidate for the development of novel antiviral agents for crop protection.
天然产物是发现新型作物保护剂的宝贵资源。一系列γ-丁内酯衍生物，源自鬼臼毒素结构的简化，被合成并评估其对烟草花叶病毒（TMV）的功效。几种衍生物表现出显著的抗病毒特性，其中化合物 表现出最强的抗 TMV 活性。在 500μg/mL 时，化合物 达到 87.8%的失活效果、71.7%的保护效果和 67.7%的治疗效果，超过了商业植物病毒清除剂 和 的效果。值得注意的是，-非对映异构体（-）比 -非对映异构体（-）表现出更高的抗病毒活性。机制研究表明，-可以与 TMV 外壳蛋白结合并干扰 TMV 粒子的自组装过程。这些发现表明，化合物 ，具有简单的化学结构，可能是开发新型作物保护抗病毒剂的潜在候选物。
