Shi Menglan, Ma Yan, Li Hong, Li Fangjie, Shen Shujuan
Department of Pharmacy, Shanghai Mental Health Center, Shanghai, PR China.
J Pharm Pract. 2025 Feb;38(1):74-80. doi: 10.1177/08971900241273200. Epub 2024 Aug 6.
This research aims to summarize and discuss issues related to psychiatric drugs by using the classification system of the Pharmaceutical Care Network Europe (PCNE) and to provide a reference for the development and direction of clinical pharmacists' work in the future. Psychiatric patients who were hospitalized in our hospital from Janurary 2023 to December 2023 were enrolled. Drug-related problems (DRPs) were evaluated using the PCNE classification system (version 9.0). The types, causes, intervention plans, acceptance of intervention plans, and statuses of DRPs were analyzed. A total of 362 patients were included, covering 405 DRP cases, with an average DRP of 1.12 for each patient. All 405 DRP cases underwent interventions, with a success rate of 83.46%. The main categories of related drugs were psychotropic drugs (70.37%), anti-infective drugs (8.89%), and cardiovascular system drugs (5.19%). The main DRPs were possible adverse drug events (21.24%), poor treatment effects (69.14%), and unnecessary medication treatment (9.63%). The main causes of DRPs were inappropriate drug selection (18.52%), inappropriate combinations of drugs (16.05%), and excessive drug dosage (13.58%). The PCNE classification system helps clinical pharmacists improve their ability to identify and solve DRPs faced by psychiatric departments, improve pharmaceutical care efficiency, and ensure rational drug use.
本研究旨在运用欧洲药学保健网络(PCNE)分类系统总结和讨论与精神科药物相关的问题,为未来临床药师工作的开展及方向提供参考。纳入了2023年1月至2023年12月在我院住院的精神科患者。使用PCNE分类系统(第9.0版)评估药物相关问题(DRPs)。分析了DRPs的类型、原因、干预计划、干预计划的接受情况以及DRPs的状态。共纳入362例患者,涉及405例DRP病例,平均每位患者有1.12个DRP。所有405例DRP病例均接受了干预,成功率为83.46%。相关药物的主要类别为精神药物(70.37%)、抗感染药物(8.89%)和心血管系统药物(5.19%)。主要的DRPs为可能的药物不良事件(21.24%)、治疗效果不佳(69.14%)和不必要的药物治疗(9.63%)。DRPs的主要原因是药物选择不当(18.52%)、药物联合不当(16.05%)和药物剂量过大(13.58%)。PCNE分类系统有助于临床药师提高识别和解决精神科面临的DRPs的能力,提高药学保健效率,并确保合理用药。