Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Department of Dermatology, Tampere University Hospital, Tampere, Finland.
Int Wound J. 2024 Aug;21(8):e70012. doi: 10.1111/iwj.70012.
Chronic ulcer patients form a heterogenous group of patients with various medical backgrounds. Cost-effective targeted treatment necessitates more knowledge about specific features related to different subgroups of ulcer patients. Hence, this study aimed to characterize ulcer patients according to gender and ulcer aetiology. A total of 946 consecutively recorded chronic ulcer patients in the Tampere Wound Registry (TWR) were included and data were gathered from the TWR and patient medical records. Comparisons were made between males and females and patients with venous-, arterial or mixed-, diabetic foot-, pressure- and atypical ulcers. Male patients were found to have diabetes, hypercholesterolemia and obesity significantly more often than females (59.2% vs. 39.6%; p < 0.001, 46.5% vs. 33.3%; p = 0.001, 42.7% vs. 35.9%; p = 0.017 respectively), whereas autoimmune diseases were more common among females (30.6% vs. 15.6%; p < 0.001). Recurrence of ulcers was most common among patients with venous ulcers (p < 0.001) and multimorbidity among those with diabetic foot ulcers (p < 0.001). To conclude, males with chronic ulcers would benefit particularly from lifestyle advice, multidisciplinary treatment should be targeted specifically at those with diabetic and arterial or mixed ulcers and preventive measures at those with venous ulcers.
慢性溃疡患者是一组具有不同医学背景的异质患者群体。为了实现具有成本效益的靶向治疗，我们需要更多地了解与不同亚组溃疡患者相关的特定特征。因此，本研究旨在根据性别和溃疡病因对溃疡患者进行特征描述。总共纳入了来自坦佩雷伤口登记处（TWR）的 946 例连续记录的慢性溃疡患者，数据来自 TWR 和患者病历。比较了男性和女性以及静脉性、动脉性或混合性、糖尿病足性、压力性和非典型性溃疡患者之间的差异。与女性相比，男性患者患有糖尿病、高胆固醇血症和肥胖症的比例显著更高（分别为 59.2% vs. 39.6%；p<0.001，46.5% vs. 33.3%；p=0.001，42.7% vs. 35.9%；p=0.017），而女性更常见自身免疫性疾病（30.6% vs. 15.6%；p<0.001）。静脉性溃疡患者的溃疡复发最为常见（p<0.001），糖尿病足溃疡患者的共病情况最为严重（p<0.001）。总之，患有慢性溃疡的男性尤其需要接受生活方式建议，多学科治疗应针对糖尿病和动脉性或混合性溃疡患者，预防措施应针对静脉性溃疡患者。
