Zhou Huan, Zhang Shusen, Miao Di, Cao Ruoyan
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Department of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
J Periodontol. 2025 Feb;96(2):184-191. doi: 10.1002/JPER.24-0318. Epub 2024 Aug 6.
This study aimed to investigate the relationship between the pan-immune-inflammation value (PIV) and periodontitis based on a large national survey.
In the present cross-sectional study, data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009-2014, which included a total of 10,300 participants. The categorization of periodontitis was based on the 2017 classification scheme. The PIV was determined using the formula: (neutrophils count × monocyte count × platelet count)/lymphocytes count. Restricted cubic spline and weighted multivariable logistic regression analyses were employed to evaluate the associations between the PIV with periodontitis.
The associations between PIV and stage III/IV periodontitis followed a U-shaped pattern (P < 0.001). The risk of developing stage III/IV periodontitis showed an increasing trend among participants in the first quartile (odds ratio [OR] = 1.21; 95% confidence interval [CI]: 1.01-1.46), third quartile (OR = 1.34; 95% CI: 1.11-1.61), and fourth quartile (OR = 1.47; 95% CI: 1.25-1.73) compared to those in the second quartile. Subgroup analysis indicated stronger associations of PIV with periodontitis in males (OR = 1.72, 95% CI: 1.36-2.18) and individuals with hypertension (OR = 1.78, 95% CI: 1.38-2.28) with significant interactions (P < 0.05).
There is a U-shaped association between PIV and stage III/IV periodontitis, which suggests a potential adjunctive treatment strategy for periodontitis. Higher PIV values were found to have a stronger correlation with stage III/IV periodontitis in males and individuals with hypertension. Further prospective trials are needed to confirm the validity of our results.
A U-shaped association exists between the pan-immune inflammation value and periodontitis in US adults, suggesting that maintaining a moderate immune inflammation response is crucial for periodontal health.
本研究旨在基于一项大型全国性调查，探讨全免疫炎症值（PIV）与牙周炎之间的关系。
在本横断面研究中，数据取自2009 - 2014年美国国家健康与营养检查调查（NHANES），共纳入10,300名参与者。牙周炎的分类基于2017年分类方案。PIV通过以下公式确定：（中性粒细胞计数×单核细胞计数×血小板计数）/淋巴细胞计数。采用受限立方样条和加权多变量逻辑回归分析来评估PIV与牙周炎之间的关联。
PIV与III/IV期牙周炎之间的关联呈U形模式（P < 0.001）。与第二四分位数的参与者相比，第一四分位数（优势比[OR] = 1.21；95%置信区间[CI]：1.01 - 1.46）、第三四分位数（OR = 1.34；95% CI：1.11 - 1.61）和第四四分位数（OR = 1.47；95% CI：1.25 - 1.73）的参与者发生III/IV期牙周炎的风险呈上升趋势。亚组分析表明，PIV与男性牙周炎（OR = 1.72，95% CI：1.36 - 2.18）和高血压个体牙周炎（OR = 1.78，95% CI：1.38 - 2.28）的关联更强，且存在显著交互作用（P < 0.05）。
PIV与III/IV期牙周炎之间存在U形关联，这提示了一种潜在的牙周炎辅助治疗策略。发现较高的PIV值与男性和高血压个体的III/IV期牙周炎相关性更强。需要进一步的前瞻性试验来证实我们结果的有效性。
美国成年人的全免疫炎症值与牙周炎之间存在U形关联，这表明维持适度的免疫炎症反应对牙周健康至关重要。
