Han Ye, Sun Yuzhe, Shu Chang, Yue Zhaoguo, Chang Xiaochi, Lin Cheng, Zhang Jie, Liu Kaining, Hou Jianxia
Department of Periodontology, National Center of Stomatology & National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing, China.
J Dent Sci. 2025 Apr;20(2):995-1001. doi: 10.1016/j.jds.2024.10.028. Epub 2024 Nov 12.
The disorders of iron metabolism in periodontal diseases have been reported, however, there is still lack of comprehensive and thorough analyses about the association between periodontitis and iron metabolism disorders. This study aimed to examine the association between periodontitis and iron metabolism disorders, and to analyze the characteristic changes of iron metabolism in periodontitis patients.
79 Stage III/IV periodontitis patients and 79 healthy controls were enrolled in this study. Periodontal clinical parameters, system inflammation markers, iron metabolism parameters and hematological parameters were collected and compared at baseline and 3 months after non-surgical periodontal therapy.
Stage III/IV periodontitis patients exhibited higher levels of systemic inflammatory markers including white blood cell (WBC) counts and high-sensitivity C-reactive protein (hs- CRP). Serum hepcidin and ferritin were significantly increased in the periodontitis group, meanwhile serum iron and transferrin were significantly decreased. Periodontal therapy attenuated the higher levels of hepcidin and ferritin, and the lower levels of Fe and transferrin in periodontitis patients at 3 months after therapy. Probing depth (PD), bleeding index (BI) and clinical attachment loss (CAL) were positively correlated with hepcidin and ferritin, and negatively correlated with Fe and transferrin respectively. Hepcidin was significantly negatively correlated with Fe and positively correlated with ferritin in periodontitis patients.
Our findings suggest the association between periodontitis and iron metabolism disorders and indicate that periodontitis-activated host responses may increase the risk of iron metabolism disorders, while meaningfully provide new insights into the systemic effects of periodontitis.
牙周疾病中铁代谢紊乱已有报道，然而，对于牙周炎与铁代谢紊乱之间的关联仍缺乏全面深入的分析。本研究旨在探讨牙周炎与铁代谢紊乱之间的关联，并分析牙周炎患者铁代谢的特征性变化。
本研究纳入了79例III/IV期牙周炎患者和79例健康对照者。收集并比较了基线时以及非手术牙周治疗3个月后的牙周临床参数、全身炎症标志物、铁代谢参数和血液学参数。
III/IV期牙周炎患者表现出较高水平的全身炎症标志物，包括白细胞（WBC）计数和高敏C反应蛋白（hs-CRP）。牙周炎组血清铁调素和铁蛋白显著升高，同时血清铁和转铁蛋白显著降低。牙周治疗使牙周炎患者在治疗3个月后铁调素和铁蛋白的较高水平以及铁和转铁蛋白的较低水平有所减轻。探诊深度（PD）、出血指数（BI）和临床附着丧失（CAL）分别与铁调素和铁蛋白呈正相关，与铁和转铁蛋白呈负相关。在牙周炎患者中，铁调素与铁显著负相关，与铁蛋白显著正相关。
我们的研究结果表明牙周炎与铁代谢紊乱之间存在关联，并表明牙周炎激活的宿主反应可能增加铁代谢紊乱的风险，同时为牙周炎的全身影响提供了新的见解。
