Department of Pediatrics, Japanese Red Cross Sendai Hospital, Sendai, Japan.
Kobe J Med Sci. 2024 Aug 5;70(3):E89-E92. doi: 10.24546/0100490906.
Food protein-induced enterocolitis syndrome (FPIES) caused by fish and others is prevalent in the Mediterranean regions but is less frequently reported in Japan. This case report describes a 3-year-old Japanese girl who developed FPIES triggered by multiple seafoods, including swordfish, cod, and squid. The diagnosis was confirmed through oral food challenge tests (OFC), which led to repeated vomiting and an increase in thymus and activation-regulated chemokine (TARC) levels. This case highlights the importance of considering fish-induced FPIES in the differential diagnosis of recurrent vomiting in children and suggests the potential utility of TARC levels in diagnosing and monitoring FPIES.
食物蛋白诱导的肠炎综合征（FPIES）由鱼类和其他食物引起，在地中海地区较为普遍，但在日本的报道较少。本病例报告描述了一例 3 岁日本女孩，因食用多种海鲜（包括箭鱼、鳕鱼和鱿鱼）而引发 FPIES。通过口服食物激发试验（OFC）确诊，该患儿出现反复呕吐，且胸腺和激活调节趋化因子（TARC）水平升高。本病例强调了在儿童反复呕吐的鉴别诊断中考虑鱼类引起的 FPIES 的重要性，并提示 TARC 水平在 FPIES 的诊断和监测中可能具有一定的应用价值。
