Kumar Virender, Tanwar Neha, Goel Muskan, Khan Mohit, Kumar Davinder, Singh Gajendra, Mundlia Jyoti, Khatri Naveen, Kumar Ashwani
College of Pharmacy, Pandit Bhagwat Dayal Sharma University of Health Sciences, 124001, Rohtak.
Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyalaya, Haridwar.
Recent Adv Food Nutr Agric. 2024 Aug 6. doi: 10.2174/012772574X311177240710100118.
Antioxidants play a pivotal role in maintaining skin health and integrity, combating the deleterious effects of oxidative stress induced by environmental aggressors such as UV ra-diation, pollution, and lifestyle factors. This paper reviews the contributions of key antioxidants, including Vitamin C, Vitamin E, Vitamin A, green tea extract, Coenzyme Q10, Resveratrol, Selenium, and Polyphenols, in skin health care. Vitamin C, known for its collagen synthesis promotion and photoprotection properties, alongside Vitamin E, a lipid-soluble antioxidant, syn-ergistically works to neutralize free radicals and repair damaged skin cells. Vitamin A, in the form of retinol, plays a critical role in skin cell regeneration and the maintenance of skin integ-rity. Green tea extract, rich in Polyphenols, offers anti-inflammatory and anticarcinogenic prop-erties, making it a potent ingredient for skin protection. Coenzyme Q10, a naturally occurring antioxidant in the body, aids in energy production for cell repair and regeneration, while Resveratrol, found in grapes and berries, provides anti-ageing benefits by enhancing skin's re-sistance to oxidative stress. Selenium, an essential mineral, contributes to the protection of skin cells from oxidative damage. The incorporation of these antioxidants in skincare products and dietary sources is discussed, highlighting the importance of a holistic approach in skincare re-gimes. The paper emphasizes the synergy between topical applications and dietary intake of antioxidants, advocating for a comprehensive strategy for promoting skin health and preventing age-related skin alterations. Method: For the review article, a variety of search engines and databases were used to identify relevant articles. Furthermore, for biomedical literature focusing on antioxidants and their ef-fects on skin health, PubMed was used. Moreover, to access a wide range of scholarly articles, including those related to dermatology and skincare, Google Scholar was used. Scopus provides comprehensive coverage of peer-reviewed literature across various scientific disciplines. Web of Science identifies high-impact articles and research on antioxidants in skincare. In addition, for accessing full-text articles on antioxidants and their applications in dermatology, Science Direct was used. The inclusion criteria for the review paper were as follows: only studies pub-lished in peer-reviewed journals were included to ensure the credibility and reliability of the information. Articles published in English were considered, to avoid language-related biases and ensure comprehension. Studies published within the last 10 years were included to provide the most current insights into antioxidant research in skincare. Articles must specifically focus on the role of antioxidants (Vitamin C, Vitamin E, Vitamin A, green tea extract, Coenzyme Q10, Resveratrol, Selenium, Polyphenols) in skin health care. Both experimental studies (in vivo and in vitro) and clinical trials were included to provide a comprehensive overview of the antioxidant effects. Full-text articles were included to allow for thorough data extraction and analysis. The exclusion criteria for the review paper were as follows: Publications that were not peer-re-viewed, such as editorials, opinion pieces, and non-scholarly articles, were excluded. Articles published in languages other than English were excluded due to potential translation challenges and to maintain consistency. Studies that did not focus on the specified antioxidants or their impact on skin health were excluded. Duplicate publications were excluded to avoid redundancy in the review. Articles with insufficient or incomplete data were excluded to ensure the quality and reliability of the review findings.
抗氧化剂在维持皮肤健康和完整性方面发挥着关键作用,可对抗由紫外线辐射、污染和生活方式因素等环境侵害所引发的氧化应激的有害影响。本文综述了关键抗氧化剂,包括维生素C、维生素E、维生素A、绿茶提取物、辅酶Q10、白藜芦醇、硒和多酚类物质在皮肤保健中的作用。维生素C以其促进胶原蛋白合成和光保护特性而闻名,与脂溶性抗氧化剂维生素E协同作用,中和自由基并修复受损皮肤细胞。视黄醇形式的维生素A在皮肤细胞再生和维持皮肤完整性方面起着关键作用。富含多酚类物质的绿茶提取物具有抗炎和抗癌特性,使其成为皮肤保护的有效成分。辅酶Q10是体内天然存在的抗氧化剂,有助于为细胞修复和再生提供能量,而葡萄和浆果中含有的白藜芦醇通过增强皮肤对氧化应激的抵抗力提供抗衰老益处。硒作为一种必需矿物质,有助于保护皮肤细胞免受氧化损伤。本文讨论了这些抗氧化剂在护肤品和饮食来源中的应用,强调了整体护肤方法的重要性。本文强调了抗氧化剂局部应用和饮食摄入之间的协同作用,倡导采用综合策略促进皮肤健康并预防与年龄相关的皮肤变化。方法:对于这篇综述文章,使用了多种搜索引擎和数据库来识别相关文章。此外,对于专注于抗氧化剂及其对皮肤健康影响的生物医学文献,使用了PubMed。此外,为了获取广泛的学术文章,包括与皮肤病学和护肤相关的文章,使用了谷歌学术。Scopus全面涵盖了各个科学学科的同行评审文献。科学网识别了护肤品中抗氧化剂的高影响力文章和研究。此外,为了获取关于抗氧化剂及其在皮肤病学中的应用的全文文章,使用了ScienceDirect。综述文章的纳入标准如下:仅纳入在同行评审期刊上发表的研究,以确保信息的可信度和可靠性。考虑发表于英文的文章,以避免语言相关偏差并确保理解。纳入过去10年内发表的研究,以提供护肤品抗氧化研究的最新见解。文章必须具体关注抗氧化剂(维生素C、维生素E、维生素A、绿茶提取物、辅酶Q10、白藜芦醇、硒、多酚类物质)在皮肤保健中的作用。纳入实验研究(体内和体外)和临床试验,以全面概述抗氧化剂的作用。纳入全文文章以进行全面的数据提取和分析。综述文章的排除标准如下:未经过同行评审的出版物,如社论、观点文章和非学术文章,被排除。由于潜在的翻译挑战并保持一致性,排除非英文发表的文章。未关注指定抗氧化剂或其对皮肤健康影响的研究被排除。排除重复出版物以避免综述中的冗余。排除数据不足或不完整的文章以确保综述结果的质量和可靠性。