Lain Edward Ted, Agrawal Nick, Ruvolo Eduardo, Weise Julia M, Callender Valerie D
Dr. Lain is with Sanova Dermatology in Austin, Texas.
Messrs. Agrawal and Ruvolo are with Beiersdorf, Inc, IC in Florham Park, New Jersey.
J Clin Aesthet Dermatol. 2024 Aug;17(8):50-55.
Coenzyme Q10 (CoQ10) is a naturally produced, lipid-soluble molecule crucial for cellular energy production and antioxidant activity. It diminishes with age and under external stress factors in skin, leading to signs of aging. Beyond its role in cellular energy production within the mitochondria, CoQ10 is vital to skin's defense against oxidative stress, a key contributor to premature aging. Use of topical skincare products with CoQ10 can be effective to replenish levels of CoQ10 and reverse skin aging.
This publication discusses the role of CoQ10 in skin aging along with the benefits of topical skincare products that incorporate CoQ10 as an ingredient.
We searched the PubMed database using terms "Coenzyme Q10" and "skin" and "aging." Overall, the search yielded 80 results, but a limitation of 10 years was then applied to restrict publications to those with the most up-to-date science.
A total of 36 publications were identified and included as background for this article. These 36 publications encompassed both original research articles and review articles.
Applying topical skincare products with CoQ10 replenishes CoQ10 cellular levels, helping to normalize cellular energy homeostasis and providing antioxidative effects to support and repair cutaneous damage including signs of skin aging. In and studies, application of CoQ10 increased CoQ10 levels both on the skin surface (i.e., stratum corneum) and even more in deeper levels of the skin. Clinically, topical application of CoQ10-formulated products reduces the depth of cutaneous wrinkles, a sign associated with aging.
Aging and stressed skin are, in part, the result of alterations in cellular metabolic homeostasis, which can be reversed via the benefits of topical application of CoQ10-enriched formulations that stimulate cutaneous energy metabolism and reduce free radicals via antioxidant function. By restoring physiological homeostasis, topical skincare products with CoQ10 replenish the skin's antioxidant levels, increase cellular (energy) metabolism, and reduce the signs of skin aging.
辅酶Q10（CoQ10）是一种天然产生的脂溶性分子，对细胞能量产生和抗氧化活性至关重要。它会随着年龄增长以及皮肤受到外部压力因素的影响而减少，从而导致衰老迹象。除了在细胞线粒体内的能量产生中发挥作用外，CoQ10对皮肤抵御氧化应激也至关重要，氧化应激是导致皮肤过早衰老的关键因素。使用含CoQ10的局部护肤产品可有效补充CoQ10水平并逆转皮肤衰老。
本出版物讨论CoQ10在皮肤衰老中的作用以及含有CoQ10作为成分的局部护肤产品的益处。
我们使用“辅酶Q10”、“皮肤”和“衰老”等术语在PubMed数据库中进行搜索。总体而言，搜索产生了80条结果，但随后应用了10年的限制条件，将出版物限制为那些具有最新科学依据的文献。
总共识别并纳入了36篇出版物作为本文的背景资料。这36篇出版物包括原创研究文章和综述文章。
使用含CoQ10的局部护肤产品可补充细胞内的CoQ10水平，有助于使细胞能量稳态正常化，并提供抗氧化作用以支持和修复皮肤损伤，包括皮肤衰老迹象。在[具体研究]和[具体研究]中，CoQ10的应用增加了皮肤表面（即角质层）以及皮肤更深层的CoQ10水平。临床上，局部应用含CoQ10配方的产品可减少皮肤皱纹深度，这是与衰老相关的一个迹象。
衰老和受压力影响的皮肤部分是细胞代谢稳态改变的结果，通过局部应用富含CoQ10的配方产品的益处可以逆转这种改变，这些产品通过抗氧化功能刺激皮肤能量代谢并减少自由基。通过恢复生理稳态，含CoQ10的局部护肤产品可补充皮肤的抗氧化水平，增加细胞（能量）代谢，并减少皮肤衰老迹象。
