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伴有横纹肌样特征的LUMB HER2+亚型浸润性小叶癌与叶状肿瘤同步恶性转化并存:越南一种极为罕见的临床病理特征。

Infiltrating lobular carcinoma of LUMB HER2+ subtype with rhabdoid feature coexisting with synchronous malignant transformation of phyllodes tumor: An exceedingly rare clinicopathological characteristic in Vietnam.

作者信息

Do Tu Anh, Mai Nhung Thi, Nguyen Duong Ngoc, Pham Khoa Hong, Le Duc Thanh, Van Pham Hung, Van Nguyen Chu

机构信息

National Cancer Hospital Vietnam, Hanoi, Vietnam.

National Institute for Control of Vaccine and Biologicals, Vietnam.

出版信息

Rare Tumors. 2024 Aug 5;16:20363613241271665. doi: 10.1177/20363613241271665. eCollection 2024.

Abstract

The transformation of a benign phyllodes tumor (PT) into a malignant PT and/or carcinoma is extremely uncommon. We present a case of a 66-year-old female with a huge mass on the left breast which was successfully removed by surgical resection. The pathological diagnosis was infiltrating lobular carcinoma with pure rhabdoid features and the malignant transformation of a benign phyllodes tumor. The first time this rare case was reported, it is demonstrated a special phenomenon through the synchronous transformation of PT grades and the carcinomatous transformation of PT.

摘要

良性叶状肿瘤(PT)转变为恶性PT和/或癌极为罕见。我们报告一例66岁女性,其左乳有一巨大肿块,经手术切除成功。病理诊断为具有纯横纹肌样特征的浸润性小叶癌以及良性叶状肿瘤的恶性转化。首次报道这一罕见病例,通过PT分级的同步转变和PT的癌性转化展示了一种特殊现象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52eb/11301723/8af621acc8c5/10.1177_20363613241271665-fig1.jpg

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