Cisplatin resistance-related transcriptome and methylome integration identifies as a novel prognostic biomarker in small cell lung cancer.

Platinum-based chemo-resistance is the major issue for the treatment of small cell lung cancer (SCLC). The integrative analysis of multi-omics data is a reliable approach for discovering novel biomarkers associated with chemo-resistance. Here, multi-omics integrative analysis and Cox regression found that higher expression of was associated with poorer survival of SCLC patients who received chemotherapy. gene was hypomethylated and upregulated in SCLC, which was validated in the levels of promoter methylation, mRNA, and protein expression. Mechanistically, using bulk RNA-seq data, functional enrichment analysis indicated that higher expression was associated with lower immune infiltration. The analysis of single-cell RNA-seq (scRNA-seq) found that SCLC cells with expression exhibited the characteristics of stemness and EMT. In addition, the high expression and hypomethylation of were also significantly associated with poor survival in lung squamous cell carcinoma. In summary, is a potential prognostic biomarker of platinum-based chemotherapy in SCLC.