Cao Hui-Hui, Li Hong, Guo Xiao-Hong, Cao Zhi-Xing, Zhang Bo-Hui
Department of Pathology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai 519000, Guangdong Province, China.
World J Clin Cases. 2024 Aug 6;12(22):5124-5130. doi: 10.12998/wjcc.v12.i22.5124.
Eosinophilic solid and cystic (ESC) renal cell carcinoma (RCC), a unique and emerging subtype of RCC, has an indolent nature; in some rare instances, it may exhibit metastatic potential. Current cases are inadequate to precisely predict the clinical outcome of ESC RCC and determine treatment choices.
Herein, we report two patients with ESC RCC. Patient 1 was a young woman with classical pathological characteristics. Patient 2 was a 52-year-old man with multifocal metastases, involving the pulmonary hilar and mediastinal lymph nodes, liver, brain, mesosternum, vertebra, rib, femur, and symphysis pubis. Awareness of ESC RCC, along with its characteristic architecture and immunophenotype, would contribute to making a definitive diagnosis, even on core biopsy samples.
The discovery of ESC RCC molecular signatures may provide new therapeutic strategies in the future.
嗜酸性实性和囊性（ESC）肾细胞癌（RCC）是一种独特且新出现的RCC亚型，具有惰性；在一些罕见情况下，它可能具有转移潜能。目前的病例不足以精确预测ESC RCC的临床结局并确定治疗选择。
在此，我们报告两例ESC RCC患者。患者1是一名具有典型病理特征的年轻女性。患者2是一名52岁男性，有多灶性转移，累及肺门和纵隔淋巴结、肝脏、脑、胸骨、椎骨、肋骨、股骨和耻骨联合。认识ESC RCC及其特征性结构和免疫表型，即使在核心活检样本上也有助于做出明确诊断。
ESC RCC分子特征的发现可能在未来提供新的治疗策略。
