Yang Fu, Shu Cheng-Jun, Wang Cai-Jun, Chen Ke
Department of Stomatology, Yuyao People's Hospital of Zhejiang Province, Yuyao 315400, Zhejiang Province, China.
World J Clin Cases. 2024 Aug 6;12(22):5094-5107. doi: 10.12998/wjcc.v12.i22.5094.
Many scholars have performed several clinical studies have investigated the association between chronic periodontitis (CP) and chronic kidney disease (CKD). However, there are still differences between these research results, and there is no unified conclusion. Therefore, a systematic review is required to understand this issue fully.
To explore the correlation between CP and CKD.
Literature on the correlation between CP and CKD, as well as the clinical attachment level (CAL) and pocket probing depth (PPD) of CKD and non-CKD, were retrieved from PubMed, Embase, the Cochrane Library, and Web of Science repositories until January 2024. After the effective data were extracted, data processing and statistics were performed using Stata 12.0.
Of the 22 studies, 13 were related to CP and CKD, and 9 reported CAL and PPD in patients with CKD and healthy controls. Meta-analysis of the correlation between CP and CKD revealed that CKD probability in people with CP was 1. 54 times that of healthy individuals [relative risk = 1.54, 95% confidence interval (CI): 1.40-1.70], and CP incidence in patients with CKD was 1. 98 times that of healthy individuals [overall risk (OR) = 1.98, 95%CI: 1.53-2.57]. Meta-analysis of CAL and PPD evaluations between CKD patients and healthy individuals showed that CAL and PPD levels were higher in CKD patients [standard mean difference (SMD) of CAL = 0.65, 95%CI: 0.29-1.01; SMD of PPD = 0.33, 95%CI: 0.02-0.63].
A bidirectional association exists between CP and CKD. CKD risk is increased in CP patients and vice versa. Periodontal tissue or tooth loss risks increase over time in CKD patients.
许多学者开展了多项临床研究，调查慢性牙周炎（CP）与慢性肾脏病（CKD）之间的关联。然而，这些研究结果仍存在差异，尚无统一结论。因此，需要进行系统评价以全面了解这一问题。
探讨CP与CKD之间的相关性。
从PubMed、Embase、Cochrane图书馆和Web of Science数据库中检索截至2024年1月关于CP与CKD相关性以及CKD和非CKD患者的临床附着水平（CAL）和探诊深度（PPD）的文献。提取有效数据后，使用Stata 12.0进行数据处理和统计分析。
22项研究中，13项与CP和CKD相关，9项报告了CKD患者和健康对照者的CAL和PPD。对CP与CKD相关性的荟萃分析显示，CP患者患CKD的概率是健康个体的1.54倍[相对风险=1.54，95%置信区间（CI）：1.40 - 1.70]，CKD患者患CP的发生率是健康个体的1.98倍[总体风险（OR）=1.98，95%CI：1.53 - 2.57]。对CKD患者和健康个体之间CAL和PPD评估的荟萃分析表明，CKD患者的CAL和PPD水平更高[CAL的标准化均数差（SMD）=0.65，95%CI：0.29 - 1.01；PPD的SMD = 0.33，95%CI：0.02 - 0.63]。
CP与CKD之间存在双向关联。CP患者患CKD的风险增加，反之亦然。CKD患者的牙周组织或牙齿缺失风险会随时间增加。
