Department of Oral Health Sciences, Faculty of Health and Welfare, Tokushima Bunri University, 180 Nishihamaboji Yamashirocho Tokushima, 770-8514, Japan.
Tokushima Dental Association, 1-8-65 Kitatamiya, Tokushima 770-0003, Japan.
J Diabetes Res. 2020 Jun 7;2020:4042129. doi: 10.1155/2020/4042129. eCollection 2020.
Oral health status is known to be associated with lifestyle-related diseases such as diabetes and chronic kidney disease. In Japan, around 40% of hemodialysis cases are patients with diabetic nephropathy. The aim of this study was to clarify the association between oral health status and diabetic nephropathy-related indices in Japanese middle-aged men. Sixty-six men (age range: 55-64 years) with ≥20 remaining teeth and who received public medical checkups and oral examinations were enrolled. We examined correlations of age, body mass index, HbA1c, HDL-C, LDL-C, neutral fat, serum creatinine, and the estimated glomerular filtration rate (eGFR) with the number of remaining teeth or the community periodontal index (CPI) score (periodontal pocket < 4 mm: 0, 4-6 mm: 1, ≥6 mm: 2). A positive correlation between the CPI score and serum creatinine and a negative correlation between CPI score and eGFR (Spearman's rank correlation coefficient, = 0.459, < 0.01, and = -0.460, < 0.01, respectively) were observed. The mean eGFR in the CPI score 0 group was significantly higher than that in the CPI score 1/2 group (82.6 vs. 70.7, Student's -test, < 0.01). Logistic regression analysis using eGFR as a dependent variable and age, CPI score, body mass index, HbA1c, and neutral fat as independent variables suggested that low eGFR (<60) could be attributed to CPI score (OR = 3.169, 95% CI: 1.031-9.742, = 0.044). These results suggest a possible association between periodontal status and renal function in Japanese middle-aged men. Periodontal condition is controlled by oral prophylaxis, and periodontal disease and chronic kidney disease have some common risk factors. Thus, periodontal management can contribute to the prevention of severe chronic kidney disease.
口腔健康状况与糖尿病和慢性肾脏病等与生活方式相关的疾病有关。在日本,约有 40%的血液透析病例是糖尿病肾病患者。本研究旨在阐明日本中年男性的口腔健康状况与糖尿病肾病相关指标之间的关系。纳入了 66 名(年龄 55-64 岁)至少有 20 颗剩余牙齿并接受公共体检和口腔检查的男性。我们检查了年龄、体重指数、HbA1c、HDL-C、LDL-C、中性脂肪、血清肌酐和估计肾小球滤过率(eGFR)与剩余牙齿数量或社区牙周指数(CPI)评分(牙周袋<4mm:0、4-6mm:1、≥6mm:2)之间的相关性。CPI 评分与血清肌酐呈正相关,与 eGFR 呈负相关(Spearman 等级相关系数分别为 0.459,<0.01 和 -0.460,<0.01)。CPI 评分 0 组的平均 eGFR 显著高于 CPI 评分 1/2 组(82.6 与 70.7,Student's t 检验,<0.01)。以 eGFR 为因变量,年龄、CPI 评分、体重指数、HbA1c 和中性脂肪为自变量的 logistic 回归分析表明,低 eGFR(<60)可能归因于 CPI 评分(OR=3.169,95%CI:1.031-9.742,=0.044)。这些结果表明,日本中年男性的牙周状况与肾功能之间可能存在关联。牙周状况由口腔预防控制,牙周病和慢性肾脏病有一些共同的危险因素。因此,牙周管理有助于预防严重的慢性肾脏病。