Cai Jia-Wei, Li Meng-Yao, Wang Wei-Hao, Shi Hong-Qi, Yang Yi-Hui, Chen Jia-Jun
Department of Pathology, Jinhua Hospital, Jinhua 321000, Zhejiang Province, China.
Department of Pathology, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang Province, China.
World J Clin Cases. 2024 Aug 6;12(22):5263-5270. doi: 10.12998/wjcc.v12.i22.5263.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and clinically aggressive hematologic malignancy originating from the precursors of plasmacytoid dendritic cells. BPDCN often involves the skin, lymph nodes, and bone marrow, with rapid clinical progression and a poor prognosis. The BPDCN diagnosis is mainly based on the immunophenotype.
In this paper, we retrospectively analyzed 2 cases of BPDCN. Both patients were elderly males. The lesions manifested as skin masses. Morphological manifestations included diffuse and dense tumor cell infiltration of the dermis and subcutaneous tissues. Immunohistochemistry staining showed that cluster of differentiation CD4, CD56, CD43, and CD123 were positive.
In this paper, we retrospectively analyzed 2 cases of BPDCN. Both patients were elderly males. The lesions manifested as skin masses. Morphological manifestations included diffuse and dense tumor cell infiltration of the dermis and subcutaneous tissues. Immunohistochemistry staining showed that cluster of differentiation CD4, CD56, CD43, and CD123 were positive.
母细胞性浆细胞样树突状细胞肿瘤（BPDCN）是一种罕见的、临床侵袭性血液系统恶性肿瘤，起源于浆细胞样树突状细胞前体。BPDCN常累及皮肤、淋巴结和骨髓，临床进展迅速，预后较差。BPDCN的诊断主要基于免疫表型。
本文回顾性分析了2例BPDCN患者。两名患者均为老年男性。病变表现为皮肤肿块。形态学表现包括真皮和皮下组织弥漫性密集的肿瘤细胞浸润。免疫组织化学染色显示分化簇CD4、CD56、CD43和CD123呈阳性。
本文回顾性分析了2例BPDCN患者。两名患者均为老年男性。病变表现为皮肤肿块。形态学表现包括真皮和皮下组织弥漫性密集的肿瘤细胞浸润。免疫组织化学染色显示分化簇CD4、CD56、CD43和CD123呈阳性。
