Wang Li-Ping, Hu Zhong-Hua, Jiang Jun-Sheng, Jin Jie
Department of Pediatrics, The First People's Hospital of Linping District, Hangzhou 310000, Zhejiang Province, China.
Department of Pediatrics, Changzhou Children Hospital, Changzhou 213100, Jiangsu Province, China.
World J Clin Cases. 2024 Aug 6;12(22):4940-4946. doi: 10.12998/wjcc.v12.i22.4940.
pneumonia (MPP) significantly impacts pediatric health, necessitating markers for early severe disease identification.
To investigate the correlation between serum inflammatory marker and the severity of MPP in children.
A prospective study was carried out from January 2023 to November 2023. A total of 160 children with MPP who underwent treatment were selected: 80 had severe MPP and 80 had mild MPP. Clinical and laboratory data were collected at the time of hospital admission and during hospitalization. Receiver operating characteristic curves were utilized to assess the diagnostic and prognostic for severe MPP.
Fever duration and length of hospitalization in pediatric patients with severe MPP exceeded those with mild MPP. The incidence of pleural effusion, lung consolidation, and bronchopneumonia on imaging was markedly elevated in the severe MPP cohort compared to the mild MPP cohort. In contrast to the mild cohort, there was a notable increase in C-reactive protein (CRP), procalcitonin (PCT), erythrocyte sedimentation rate, lactic dehydrogenase, D-dimer, and inflammatory cytokines [interleukin (IL)-6, IL-8, IL-10 and tumor necrosis factor (TNF)-α] in the severe MPP group were significantly higher.
Serum inflammatory markers (CRP, PCT, IL-6, D-dimer, IL-10 and TNF-α) were considered as predictors in children with severe MPP.
肺炎支原体肺炎（MPP）对儿童健康有重大影响，因此需要用于早期识别重症疾病的标志物。
探讨儿童MPP血清炎症标志物与疾病严重程度之间的相关性。
于2023年1月至2023年11月开展一项前瞻性研究。共选取160例接受治疗的MPP患儿：80例为重症MPP，80例为轻症MPP。在入院时及住院期间收集临床和实验室数据。采用受试者工作特征曲线评估重症MPP的诊断和预后情况。
重症MPP患儿的发热持续时间和住院时长超过轻症MPP患儿。与轻症MPP队列相比，重症MPP队列影像学上胸腔积液、肺实变及支气管肺炎的发生率明显升高。与轻症队列相比，重症MPP组的C反应蛋白（CRP）、降钙素原（PCT）、红细胞沉降率、乳酸脱氢酶、D-二聚体及炎症细胞因子[白细胞介素（IL）-6、IL-8、IL-10和肿瘤坏死因子（TNF）-α]显著升高。
血清炎症标志物（CRP、PCT、IL-6、D-二聚体、IL-10和TNF-α）可作为重症MPP患儿的预测指标。
