Pediatrics, Nanjing Integrated Traditional |Chinese and Western Medicine Hospital, Nanjing City, Jiangsu province, 211800, China.
Pediatrics, Nanjing Integrated Traditional |Chinese and Western Medicine Hospital, Nanjing City, Jiangsu province, 211800, China.
Microb Pathog. 2021 Jun;155:104893. doi: 10.1016/j.micpath.2021.104893. Epub 2021 Apr 29.
The etiology of childhood asthma is multifactorial, atypical bacterial pathogens, including Mycoplasma pneumoniae, have been proposed as possible risk factors or contributors. This review aims to assess the possible association between M. pneumoniae infection and childhood asthma. We searched major international literature databases (up to January 10, 2021) to identify relevant studies. We used a random-effects meta-analysis (REM) model to generate the pooled odds ratio (OR) and 95% confidence intervals (CIs). Several subgroups analyses were performed concerning the IgG, IgM, and DNA detection of M. pneumoniae infection. We included 22 eligible studies; these studies involved a total of 5064 children. We found that there was a statistically significant association between M. pneumoniae infection, as determined by IgM serology (OR, 3.13; 95% CI, 1.78-5.48), and DNA detection (OR, 1.57; 95% CI, 1.25-1.97) with increased risk of any type of childhood asthma. Moreover, children with acute asthma had significantly higher seropositivity for anti- M. pneumoniae IgM antibodies (OR, 4.43; 95% CI, 2.80-7.02) than children with stable asthma. Although our findings indicate a positive association between M. pneumoniae infection and childhood asthma, well-designed and -controlled studies are need in the future to rigorously test this association and identify the underlying mechanisms.
儿童哮喘的病因是多因素的，非典型细菌病原体，包括肺炎支原体，被认为是可能的危险因素或促成因素。本综述旨在评估肺炎支原体感染与儿童哮喘之间可能存在的关联。我们检索了主要的国际文献数据库（截至 2021 年 1 月 10 日）以确定相关研究。我们使用随机效应荟萃分析（REM）模型生成合并优势比（OR）和 95%置信区间（CI）。我们针对肺炎支原体感染的 IgG、IgM 和 DNA 检测进行了几项亚组分析。我们纳入了 22 项符合条件的研究；这些研究共涉及 5064 名儿童。我们发现，肺炎支原体感染与 IgM 血清学（OR，3.13；95%CI，1.78-5.48）和 DNA 检测（OR，1.57；95%CI，1.25-1.97）之间存在统计学显著关联，增加了任何类型儿童哮喘的风险。此外，患有急性哮喘的儿童抗肺炎支原体 IgM 抗体的血清阳性率明显高于患有稳定型哮喘的儿童（OR，4.43；95%CI，2.80-7.02）。尽管我们的研究结果表明肺炎支原体感染与儿童哮喘之间存在正相关，但未来仍需要进行精心设计和控制良好的研究来严格检验这种关联并确定潜在机制。
