• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

疑似白喉类毒素和破伤风类毒素（dTdap）加强疫苗诱发的体位性直立性心动过速综合征（POTS）。

Suspected Diphtheria Toxoid and Tetanus Toxoid (dTdap) Booster Vaccine-Induced Postural Orthostatic Tachycardia Syndrome (POTS).

作者信息

Katwaroo Arun R, Chandolu Krishna Mohan, Seecheran Valmiki K, Ramcharan Priya, Seecheran Rajeev V, Giddings Stanley, Bhagwandass Neal, Seecheran Naveen A

机构信息

Internal Medicine, Trinidad Institute of Medical Technology, St. Augustine, TTO.

Public Health, Eastern Regional Health Authority, Sangre Grande, TTO.

出版信息

Cureus. 2024 Jul 7;16(7):e64008. doi: 10.7759/cureus.64008. eCollection 2024 Jul.

DOI:10.7759/cureus.64008
PMID:39109119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11301768/
Abstract

We describe a case of a 40-year-old South Asian woman who presented with symptoms suggestive of postural orthostatic tachycardia syndrome (POTS) following a diphtheria toxoid and tetanus toxoid (dTdap) booster vaccination administered one week prior. The patient's POTS responded favorably to treatment with low-dose fludrocortisone and ivabradine. Clinicians should maintain a high index of suspicion for POTS as a possible vaccine adverse event (VAE) post-dTdap booster inoculation and be aware of appropriate management strategies.

摘要

我们描述了一例40岁的南亚女性病例，该患者在一周前接种白喉类毒素和破伤风类毒素（dTdap）加强疫苗后，出现了提示体位性直立性心动过速综合征（POTS）的症状。患者的POTS对小剂量氟氢可的松和伊伐布雷定治疗反应良好。临床医生应高度怀疑POTS是dTdap加强接种后可能出现的疫苗不良事件（VAE），并了解适当的管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b868/11301768/df408971718e/cureus-0016-00000064008-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b868/11301768/678f55d295d6/cureus-0016-00000064008-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b868/11301768/df408971718e/cureus-0016-00000064008-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b868/11301768/678f55d295d6/cureus-0016-00000064008-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b868/11301768/df408971718e/cureus-0016-00000064008-i02.jpg

相似文献

1
Suspected Diphtheria Toxoid and Tetanus Toxoid (dTdap) Booster Vaccine-Induced Postural Orthostatic Tachycardia Syndrome (POTS).疑似白喉类毒素和破伤风类毒素（dTdap）加强疫苗诱发的体位性直立性心动过速综合征（POTS）。
Cureus. 2024 Jul 7;16(7):e64008. doi: 10.7759/cureus.64008. eCollection 2024 Jul.
2
Suspected COVID-19 mRNA Vaccine-Induced Postural Orthostatic Tachycardia Syndrome.疑似新型冠状病毒病信使核糖核酸疫苗诱导的体位性直立性心动过速综合征
Cureus. 2023 Jan 26;15(1):e34236. doi: 10.7759/cureus.34236. eCollection 2023 Jan.
3
Levels of antibodies specific to diphtheria toxoid, tetanus toxoid, and Haemophilus influenzae type b in healthy children born to Tdap-vaccinated mothers.健康母亲 Tdap 疫苗接种后所生儿童针对白喉类毒素、破伤风类毒素和乙型流感嗜血杆菌的抗体水平。
Vaccine. 2020 Oct 14;38(44):6914-6921. doi: 10.1016/j.vaccine.2020.08.058. Epub 2020 Sep 2.
4
Safety and immunogenicity of SIIPL Tdap, a new tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine, in healthy subjects 4-65 years of age: A Phase II/III randomized, observer-blinded, active controlled, multicenter clinical study in Germany.SIIPL Tdap，一种新型的破伤风类毒素、白喉类毒素和无细胞百日咳疫苗，在 4-65 岁健康受试者中的安全性和免疫原性：一项在德国进行的 II/III 期、随机、观察者设盲、主动对照、多中心临床研究。
Vaccine. 2023 Nov 2;41(46):6810-6819. doi: 10.1016/j.vaccine.2023.09.060. Epub 2023 Oct 10.
5
Diphtheria, tetanus and pertussis antibodies in 10-year-old children before and after a booster dose of three toxoids: implications for the timing of a booster dose.10岁儿童在接种三价类毒素加强剂量前后的白喉、破伤风和百日咳抗体：对加强剂量接种时间的影响
Eur J Pediatr. 2006 Jan;165(1):14-8. doi: 10.1007/s00431-005-1763-3. Epub 2005 Oct 26.
6
Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2 infection and after COVID-19 messenger RNA vaccination.新型冠状病毒2（SARS-CoV-2）感染后及新型冠状病毒病（COVID-19）信使核糖核酸疫苗接种后出现的体位性直立性心动过速综合征及其他相关自主神经功能障碍。
Front Neurol. 2023 Aug 16;14:1221518. doi: 10.3389/fneur.2023.1221518. eCollection 2023.
7
Antibody persistence to diphtheria toxoid, tetanus toxoid, antigens, and type b following primary and first booster with pentavalent versus hexavalent vaccines.在使用五价疫苗和六价疫苗进行基础免疫和首次加强免疫后，对白喉类毒素、破伤风类毒素、抗原和 b 型的抗体持久性。
Hum Vaccin Immunother. 2024 Dec 31;20(1):2352909. doi: 10.1080/21645515.2024.2352909. Epub 2024 May 16.
8
Reports of Postural Orthostatic Tachycardia Syndrome After Human Papillomavirus Vaccination in the Vaccine Adverse Event Reporting System.疫苗不良事件报告系统中 HPV 疫苗接种后出现体位性心动过速综合征的报告。
J Adolesc Health. 2017 Nov;61(5):577-582. doi: 10.1016/j.jadohealth.2017.08.004.
9
Safety and immunogenicity of an indigenously developed tetanus toxoid, diphtheria toxoid, and acellular pertussis vaccine (Tdap) in adults, adolescents, and children in India.印度本土研发的破伤风类毒素、白喉类毒素和无细胞百日咳疫苗（Tdap）在成人、青少年和儿童中的安全性和免疫原性。
Expert Rev Vaccines. 2023 Jan-Dec;22(1):278-287. doi: 10.1080/14760584.2023.2188942.
10
Reduced-antigen, combined diphtheria, tetanus and acellular pertussis vaccine, adsorbed (Boostrix®): a review of its properties and use as a single-dose booster immunization.吸附无细胞百白破灭活、全细胞百日咳和破伤风联合疫苗（Boostrix®）：作为单剂加强免疫的特性和用途介绍。
Drugs. 2012 Sep 10;72(13):1765-91. doi: 10.2165/11209630-000000000-00000.

本文引用的文献

1
Global epidemiology and burden of tetanus from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019.1990年至2019年破伤风的全球流行病学与负担：针对《2019年全球疾病负担研究》的系统分析
Int J Infect Dis. 2023 Jul;132:118-126. doi: 10.1016/j.ijid.2023.04.402. Epub 2023 Apr 21.
2
Suspected COVID-19 mRNA Vaccine-Induced Postural Orthostatic Tachycardia Syndrome.疑似新型冠状病毒病信使核糖核酸疫苗诱导的体位性直立性心动过速综合征
Cureus. 2023 Jan 26;15(1):e34236. doi: 10.7759/cureus.34236. eCollection 2023 Jan.
3
Diagnosis and management of postural orthostatic tachycardia syndrome.
体位性直立性心动过速综合征的诊断与管理
CMAJ. 2022 Mar 14;194(10):E378-E385. doi: 10.1503/cmaj.211373.
4
Dysautonomia Following Tetanus, Diphtheria, and Pertussis Vaccine (Tdap): The First Case of Extreme Cachexia Caused by Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) in a Human.破伤风、白喉和百日咳疫苗（Tdap）接种后出现自主神经功能紊乱：首例由佐剂诱导的自身免疫/炎症综合征（ASIA 综合征）引起的极度恶病质的人类病例。
Medicina (Kaunas). 2021 Dec 6;57(12):1333. doi: 10.3390/medicina57121333.
5
A Case of Postural Orthostatic Tachycardia Syndrome Secondary to the Messenger RNA COVID-19 Vaccine.1例继发于信使核糖核酸新冠疫苗的体位性直立性心动过速综合征病例
Cureus. 2021 May 4;13(5):e14837. doi: 10.7759/cureus.14837.
6
Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infection: a case series of 20 patients.COVID-19 感染后体位性心动过速综合征（POTS）和其他自主神经障碍：20 例患者的病例系列。
Immunol Res. 2021 Apr;69(2):205-211. doi: 10.1007/s12026-021-09185-5. Epub 2021 Mar 30.
7
Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome.随机试验伊伐布雷定在高肾上腺素能体位性心动过速综合征患者。
J Am Coll Cardiol. 2021 Feb 23;77(7):861-871. doi: 10.1016/j.jacc.2020.12.029.
8
An Unusual Case of Evolving Localized Tetanus Despite Prior Immunization and Protective Antibody Titer.尽管之前进行了免疫接种且保护性抗体滴度正常，但仍出现进行性局限性破伤风的罕见病例。
Cureus. 2020 Jul 31;12(7):e9498. doi: 10.7759/cureus.9498.
9
Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature.伊伐布雷定在体位性直立性心动过速综合征中的应用：文献综述
Cureus. 2020 Apr 28;12(4):e7868. doi: 10.7759/cureus.7868.
10
Vaccine-Associated Neurological Adverse Events: A Case Report and Literature Review.疫苗相关神经系统不良事件：病例报告及文献复习。
Curr Pharm Des. 2020;25(43):4570-4578. doi: 10.2174/1381612825666191119095132.