Li Qianqian, Liu Yujie, Zhang Zulun, Zhang Sheng, Ding Xiao, Zhang Faming
Department of Microbiota Medicine & Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, People's Republic of China.
Department of Medicine & Therapeutics, the Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Nat Sci Sleep. 2024 Aug 2;16:1141-1152. doi: 10.2147/NSS.S460882. eCollection 2024.
There is scarce evidence to support the effectiveness of faecal microbiota transplantation (FMT) in improving sleep among individuals with inflammatory bowel disease (IBD). Our study aimed to evaluate the effect of washed microbiota transplantation (WMT) (the new method of FMT) on the sleep of patients with IBD in short term.
This prospective study was conducted as part of two interventional clinical trials (starting on February 2013 and expected to end on December 2025) and placed significant emphasis on evaluating sleep quality in patients with IBD. To measure subjective sleep, we used the Pittsburgh sleep quality index (PSQI). The primary endpoint was the PSQI score one month after WMT.
This stage study included 52 eligible patients evaluated by PSQI questionnaire who underwent WMT from January 2020 to March 2021 and 47 patients were enrolled for analysis. The age of the patients ranged from 13 to 60 years, with a mean of 33.4 years, and 57.4% (25/47) of the patients were male. The PSQI scores for all 47 patients one month after undergoing WMT were significantly lower (Cohen d = 0.59, p < 0.001) compared to the baseline. Moreover, baseline PSQI score was correlated with the difference value of the PSQI score before and after WMT (post-PSQI minus pre-PSQI) (r = 0.61, p < 0.05).
The study suggests that WMT might be a helpful intervention for improving the sleep quality of patients with IBD, encouraging clinicians to consider its use in clinical practice for addressing poor sleep in IBD patients.
ClinicalTrials.gov; ID: NCT01793831, NCT01790061.
几乎没有证据支持粪便微生物群移植（FMT）对改善炎症性肠病（IBD）患者睡眠有效的观点。我们的研究旨在评估经洗涤的微生物群移植（WMT）（FMT的新方法）对IBD患者短期睡眠的影响。
这项前瞻性研究是两项干预性临床试验（于2013年2月开始，预计2025年12月结束）的一部分，重点评估IBD患者的睡眠质量。为了测量主观睡眠，我们使用了匹兹堡睡眠质量指数（PSQI）。主要终点是WMT后一个月的PSQI评分。
本阶段研究纳入了52例符合条件的患者，这些患者通过PSQI问卷进行评估，于2020年1月至2021年3月接受了WMT，其中47例患者被纳入分析。患者年龄在13至60岁之间，平均年龄为33.4岁，57.4%（25/47）的患者为男性。与基线相比，所有47例患者在接受WMT后一个月的PSQI评分均显著降低（Cohen d = 0.59，p < 0.001）。此外，基线PSQI评分与WMT前后PSQI评分的差值（PSQI后减去PSQI前）相关（r = 0.61，p < 0.05）。
该研究表明，WMT可能是改善IBD患者睡眠质量的一种有益干预措施，鼓励临床医生在临床实践中考虑使用它来解决IBD患者的睡眠不佳问题。
ClinicalTrials.gov；标识符：NCT01793831，NCT01790061。
