格罗布克-布莱克本-比内梅反应步入成熟：自其21岁生日（2019 - 2023年）以来的创新与改进 - Suppr

The Groebke-Blackburn-Bienaymé reaction in its maturity: innovation and improvements since its 21st birthday (2019-2023).

作者信息

Martini Cristina, Mardjan Muhammad Idham Darussalam, Basso Andrea

机构信息

Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Genova, Via Dodecaneso 31, 16146 Genova, Italy.

Department of Chemistry, Universitas Gadjah Mada, Bulaksumur, Sekip Utara, Yogyakarta 55281, Indonesia.

出版信息

Beilstein J Org Chem. 2024 Aug 1;20:1839-1879. doi: 10.3762/bjoc.20.162. eCollection 2024.

The Groebke-Blackburn-Bienaymé (GBB) three-component reaction, discovered in 1998, is a very efficient strategy to assemble imidazo[1,2-]-heterocycles starting from amidines, aldehydes and isocyanides. This review aims to exhaustively describe innovative aspects of this reaction achieved during the last five years, and classifies them into five categories: synthetic methods, building blocks, scaffolds, biological activities and physical properties.