格罗布克-布莱克本-比内梅反应步入成熟：自其21岁生日（2019 - 2023年）以来的创新与改进
The Groebke-Blackburn-Bienaymé reaction in its maturity: innovation and improvements since its 21st birthday (2019-2023).
作者信息
Martini Cristina, Mardjan Muhammad Idham Darussalam, Basso Andrea
机构信息
Dipartimento di Chimica e Chimica Industriale, Università degli Studi di Genova, Via Dodecaneso 31, 16146 Genova, Italy.
Department of Chemistry, Universitas Gadjah Mada, Bulaksumur, Sekip Utara, Yogyakarta 55281, Indonesia.
出版信息
Beilstein J Org Chem. 2024 Aug 1;20:1839-1879. doi: 10.3762/bjoc.20.162. eCollection 2024.
The Groebke-Blackburn-Bienaymé (GBB) three-component reaction, discovered in 1998, is a very efficient strategy to assemble imidazo[1,2-]-heterocycles starting from amidines, aldehydes and isocyanides. This review aims to exhaustively describe innovative aspects of this reaction achieved during the last five years, and classifies them into five categories: synthetic methods, building blocks, scaffolds, biological activities and physical properties.
1998年发现的格罗布克-布莱克本-比奈梅（GBB）三组分反应，是一种从脒、醛和异氰化物开始组装咪唑并[1,2 - ]杂环的非常有效的策略。本综述旨在详尽描述该反应在过去五年中取得的创新成果，并将其分为五类：合成方法、构建模块、骨架、生物活性和物理性质。
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