Asociación Cuerpo & Alma, Ciudad Autónoma de Buenos Aires, Argentina.
Sanatorio Otamendi, Ciudad Autónoma de Buenos Aires, Argentina.
Mem Inst Oswaldo Cruz. 2024 Aug 2;119:e240018. doi: 10.1590/0074-02760240018. eCollection 2024.
Chagas disease is a systemic illness with widespread microvascular involvement. Experimental and clinical studies suggest that functional and structural microcirculatory abnormalities might be relevant to the disease progression.
To show the presence of sublingual microcirculatory alterations in patients with chronic Chagas disease.
This was a cross-sectional study including adult patients with serologic diagnosis of Chagas disease (n = 41) and control volunteers with negative serology (n = 38), from an endemic rural population. Study participants underwent clinical, electrocardiographic, echocardiographic, and sublingual videomicroscopic assessment. Videos were acquired by a sidestream-dark-field (SDF) imaging device and evaluated by a software-assisted analysis (AVA 3.2 software).
Most of Chagas disease patients were in the indeterminate phase (n = 34) and had lower heart rate and more echocardiographic abnormalities than control group (50 vs. 26%, p = 0.03). They also exhibited higher small microvessels total and perfused vascular density (20.12 ± 2.33 vs. 19.05 ± 2.25 and 20.03 ± 2.28 vs. 19.01 ± 2.25 mm/mm2, p < 0.05 for both). Other microvascular variables did not differ between groups.
Patients with chronic Chagas disease exhibited increases in sublingual total and perfused microvascular density. Angiogenesis might be the underlying mechanism. The videomicroscopic assessment of mucosal sublingual microcirculation might be an additional tool in the monitoring of Chagas disease.
恰加斯病是一种全身性疾病，广泛涉及微血管。实验和临床研究表明，功能性和结构性微血管异常可能与疾病进展有关。
显示慢性恰加斯病患者舌下微循环改变的存在。
这是一项横断面研究，包括来自流行地区的农村人群中血清学诊断为恰加斯病的成年患者（n = 41）和血清学阴性的对照组志愿者（n = 38）。研究参与者接受了临床、心电图、超声心动图和舌下视频显微镜评估。视频由旁流暗场（SDF）成像设备采集，并通过软件辅助分析（AVA 3.2 软件）进行评估。
大多数恰加斯病患者处于不确定期（n = 34），心率较低，超声心动图异常较对照组多（50%比 26%，p = 0.03）。他们还表现出更高的小微血管总灌注血管密度（20.12 ± 2.33 比 19.05 ± 2.25 和 20.03 ± 2.28 比 19.01 ± 2.25 mm/mm2，两者均 p < 0.05）。其他微血管变量在两组之间没有差异。
慢性恰加斯病患者表现出舌下总灌注微血管密度增加。血管生成可能是潜在的机制。黏膜舌下微循环的视频显微镜评估可能是监测恰加斯病的一种额外工具。
