Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Department of Civilization Diseases, Faculty of Medicine, Collegium Medicum, Stefan Cardinal Wyszynski University in Warsaw, Warszawa, Poland.
Arq Bras Oftalmol. 2024 Aug 2;88(1):e20220236. doi: 10.5935/0004-2749.2022-0236. eCollection 2024.
This study investigated the relationship between blood pressure and intraocular pressure in treatmentnaive, non-glaucoma patients with different blood pressure statuses, focusing on the 24-h ocular volume and nocturnal blood pressure decline.
Treatment-naive, non-glaucoma patients undergoing hypertension evaluation were enrolled as study participants. Simultaneous 24-h ambulatory blood pressure measurement and 24-h ocular volume recording with a contact lens sensor. We also compared ocular volume curve parameters between normotensive and hypertensive patients, as well as between those with and without nocturnal blood pressure decline.
A total of 21 patients, including 7 normotensive and 14 treatment-naive hypertensive individuals, were included in the study. of them, 11 were dippers and 10 were non-dippers. No significant difference in the 24-h ocular volume slope was observed between the hypertensive and normotensive patients (p=0.284). However, dippers had a significantly higher 24-h ocular volume slope (p=0.004) and nocturnal contact lens sensor output (p=0.041) than non-dippers.
Nocturnal blood pressure decline, rather than the blood pressure level, is associated with the increased 24-h ocular volume slope and nocturnal ocular volume. Further studies are required to determine whether the acceleration of glaucoma progression in dippers is primarily due to low blood pressure, high intraocular pressure, or a combination of both.
本研究旨在探讨不同血压状态下未经治疗的非青光眼患者的血压与眼内压之间的关系，重点关注 24 小时眼内体积和夜间血压下降。
纳入接受高血压评估的未经治疗的非青光眼患者作为研究对象。同时进行 24 小时动态血压测量和接触镜传感器的 24 小时眼内体积记录。我们还比较了正常血压患者和高血压患者、以及夜间血压下降患者和非下降患者之间的眼内体积曲线参数。
共纳入 21 名患者，包括 7 名正常血压者和 14 名未经治疗的高血压者，其中 11 名为杓型，10 名为非杓型。高血压患者和正常血压患者的 24 小时眼内体积斜率无显著差异（p=0.284）。然而，杓型患者的 24 小时眼内体积斜率（p=0.004）和夜间接触镜传感器输出（p=0.041）显著高于非杓型患者。
夜间血压下降而不是血压水平与 24 小时眼内体积斜率和夜间眼内体积增加有关。需要进一步研究确定杓型患者青光眼进展加速是否主要是由于低血压、高眼压还是两者的结合。
