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用敷贴近距离放疗治疗原发性结膜基底细胞癌:1例罕见病例报告

Primary conjunctival basal cell carcinoma treated with plaque brachytherapy: a rare case report.

作者信息

Nag Adwaita, Krema Hatem, Saeed Kamil Zaid, Akbar Beiki-Ardakani, Laperriere Normand

机构信息

Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada.

Department of Diagnostic and Molecular Pathology, University of Toronto, Toronto, ON, Canada.

出版信息

Orbit. 2025 Jun;44(3):340-342. doi: 10.1080/01676830.2024.2387094. Epub 2024 Aug 7.

Abstract

Primary basal cell carcinoma (BCC) of the conjunctiva is a rare tumor with only six cases reported in literature. We present the case of an 81-year-old male complaining of a slow-growing lesion in his right eye for the past 3 years. The lesion in the temporal bulbar conjunctiva was gelatinous and firmly adherent to sclera. Ultrasound biomicroscopy revealed apparent scleral thinning without invasion. Our provisional diagnosis was ocular surface squamous neoplasia; however, incisional biopsy for histopathological diagnosis revealed that it was a BCC. Due to scleral adhesion and thinning, the lesion was not amenable for surgical resection. Plaque brachytherapy was used to successfully treat the lesion. To the best of our knowledge, this is the first report of brachytherapy administration for treatment of this rare cancer. Previously reported cases were all nodular or pedunculated and treated with surgical excision. For flat, adherent, or invasive lesions, plaque brachytherapy is an effective primary treatment modality.

摘要

原发性结膜基底细胞癌(BCC)是一种罕见肿瘤,文献中仅报道过6例。我们报告了一例81岁男性病例,该患者在过去3年中一直主诉右眼有一个生长缓慢的病变。颞侧球结膜处的病变呈胶冻状,与巩膜紧密粘连。超声生物显微镜检查显示巩膜明显变薄但未受侵犯。我们的初步诊断为眼表鳞状上皮肿瘤;然而,切开活检的组织病理学诊断显示为基底细胞癌。由于病变与巩膜粘连且巩膜变薄,该病变不适合手术切除。采用敷贴近距离放射治疗成功治愈了该病变。据我们所知,这是首例关于采用近距离放射治疗这种罕见癌症的报告。先前报道的病例均为结节状或带蒂的,采用手术切除治疗。对于扁平、粘连或浸润性病变,敷贴近距离放射治疗是一种有效的主要治疗方式。

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