Heidari Mohammad Mahdi, Khaledi Azad, Taravati Amir Mohammad, Rastegar-Kashkouli Ali, Moammer Farzaneh, Safari Iman
Department of Pediatrics, Kashan University of Medical Sciences Faculty of Medicine, Kashan, Iran.
Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Eurasian J Med. 2024 May 9;56(2):127-35. doi: 10.5152/eurasianjmed.2024.23330.
Cerebrovascular events are linked to ankylosing spondylitis. Accelerated atherosclerosis and endothelial dysfunction against a backdrop of inflammation have been widely blamed for the increased cerebrovascular risk in ankylosing spondylitis. The absence of a comprehensive review encouraged us to consider the link between ankylosing spondylitis and cerebrovascular diseases. Web of Science, PubMed, Medline, Scopus, and EMBASE were searched to identify studies published from 2000 to June 10, 2023. All observational and cohort studies reporting myocardial infarction or stroke and considering classic cerebrovascular risk in ankylosing spondylitis patients and healthy controls were included. Most of the included studies reported that the risk of cerebrovascular disorders was greater in ankylosing spondylitis than in the general population. Also, most studies showed that for both sexes, the prevalence of cardiovascular illnesses rose with age, and this trend was consistent across all subgroups of cardiovascular disorders. Also, most studies reported that the rate of cerebrovascular accidents in ankylosing spondylitis patients was higher than in control groups. Some studies reported that the risk of developing an ischemic stroke was higher in young patients with ankylosing spondylitis, while others did not. Our systematic analysis found that most studies agreed that ankylosing spondylitis patients had a higher risk of cerebrovascular diseases than the general population. Still, this increased risk was influenced by several factors that need further research exploration.
脑血管事件与强直性脊柱炎有关。在炎症背景下加速的动脉粥样硬化和内皮功能障碍被广泛认为是强直性脊柱炎患者脑血管疾病风险增加的原因。由于缺乏全面的综述，我们决定探讨强直性脊柱炎与脑血管疾病之间的联系。我们检索了Web of Science、PubMed、Medline、Scopus和EMBASE，以确定2000年至2023年6月10日发表的研究。纳入所有报告心肌梗死或中风，并考虑强直性脊柱炎患者和健康对照者经典脑血管疾病风险的观察性和队列研究。大多数纳入研究报告称，强直性脊柱炎患者发生脑血管疾病的风险高于普通人群。此外，大多数研究表明，无论男女，心血管疾病的患病率均随年龄增长而上升，且这一趋势在所有心血管疾病亚组中均一致。另外，大多数研究报告称，强直性脊柱炎患者的脑血管意外发生率高于对照组。一些研究报告称，年轻的强直性脊柱炎患者发生缺血性中风的风险较高，而其他研究则未发现此现象。我们的系统分析发现，大多数研究一致认为，强直性脊柱炎患者患脑血管疾病的风险高于普通人群。然而，这种风险增加受到几个因素的影响，需要进一步的研究探索。
