Tateishi Kensuke
Department of Neurosurgery, Graduate School of Medicine, Yokohama City University.
Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University.
Neurol Med Chir (Tokyo). 2024 Sep 15;64(9):323-329. doi: 10.2176/jns-nmc.2024-0078. Epub 2024 Aug 6.
Some central nervous system (CNS) malignancies are highly aggressive and urgently need innovative treatment strategies to improve prognosis. A significant concern for therapeutic development is the time-consuming nature of developing treatments for CNS tumors. Therefore, a rapid and efficient translational approach is needed to address this problem. Translational and reverse translational research aims to bridge the gap between laboratory data and clinical applications and has been developed in the field of neuro-oncology. This study presents our translational platform systems for malignant CNS tumors, which combine an intraoperative integrated diagnostic system and comprehensive in vitro and in vivo assay systems. These laboratory systems may contribute to a better understanding of tumor biology and the development of novel therapeutic strategies for the poor prognosis of CNS tumors.
一些中枢神经系统（CNS）恶性肿瘤具有高度侵袭性，迫切需要创新的治疗策略来改善预后。治疗开发中的一个重大问题是开发中枢神经系统肿瘤治疗方法耗时较长。因此，需要一种快速有效的转化方法来解决这一问题。转化研究和反向转化研究旨在弥合实验室数据与临床应用之间的差距，并且已在神经肿瘤学领域得到发展。本研究展示了我们针对恶性中枢神经系统肿瘤的转化平台系统，该系统结合了术中综合诊断系统以及全面的体外和体内检测系统。这些实验室系统可能有助于更好地理解肿瘤生物学，并为中枢神经系统肿瘤的不良预后开发新的治疗策略。
