美国成年人甘油三酯血糖指数与痛风之间的关联。

Association between triglyceride glycemic index and gout in US adults.

作者信息

Li Tao, Zhang Huilan, Wu Qianyu, Guo Siwei, Hu Wanqin

机构信息

Department of Pathophysiology, Medical College, Jiaying University, Meizhou, Guangdong Province, China.

Department of Nursing, Medical College, Jiaying University, Meizhou, Guangdong Province, China.

出版信息

J Health Popul Nutr. 2024 Aug 7;43(1):115. doi: 10.1186/s41043-024-00613-4.

DOI:10.1186/s41043-024-00613-4

PMID:39113110

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11308556/

Abstract

BACKGROUND

Insulin resistance (IR) has been linked to the development of gout. The triglyceride glycemic (TyG) index is a useful biomarker of IR, and the evidences between TyG and gout are limited. Therefore, this study aimed to examine the association between the TyG index and gout in the United States (U.S).

METHODS

The cross-sectional study was conducted among adults with complete TyG index and gout data in the 2007-2017 National Health and Nutrition Examination Survey (NHANES). The TyG index was calculated as fasting triglycerides (mg/dl) * fasting glucose (mg/dl)/2. Gout was assessed by self-report questionnaire (MCQ160n). Weighted chi-squared and weighted Student's t-test were used to assess group differences. Weighted multivariable logistic regression analysis, subgroup analysis, and interaction tests were used to examine the TyG index and gout association.

RESULTS

The final participants were 11,768; 5910 (50.32%) were female, 7784 (73.26%) were 18-60 years old, 5232 (69.63%) were white, and 573 (5.12%) had gout. After adjusting for all covariates, the TyG index was positively associated with gout; each unit increase in TyG index was associated with 40% higher odds of gout (odds ratio (OR), 1.40; 95% CI: 1.82-2.66; p < 0.0001). Participants in the highest TyG index tertile group were at high risk of gout (odds ratio (OR), 1.64; 95% CI: 1.06-2.54, p = 0.03) versus those in the lowest tertile group. Interaction tests showed no significant effect of age, race, marital status, PIR level, education, BMI, smoking status, drinking status, hypertension, and DM on this association between TyG index and gout (p for interaction > 0.05).

CONCLUSIONS

In this large cross-sectional study, our results suggested that a higher TyG index was associated with an increased likelihood of gout in U.S. adults. Our findings highlight that the TyG index is a reliable biomarker of IR; management of IR among adults may prevent or alleviate the development of gout; meanwhile, the TyG index may be a simple and cost-effective method to detect gout.

摘要

背景

胰岛素抵抗（IR）与痛风的发生有关。甘油三酯血糖（TyG）指数是一种有用的IR生物标志物，而TyG与痛风之间的证据有限。因此，本研究旨在探讨美国成年人中TyG指数与痛风之间的关联。

方法

在2007 - 2017年国家健康与营养检查调查（NHANES）中，对具有完整TyG指数和痛风数据的成年人进行横断面研究。TyG指数的计算方法为空腹甘油三酯（mg/dl）×空腹血糖（mg/dl）/2。痛风通过自我报告问卷（MCQ160n）进行评估。采用加权卡方检验和加权学生t检验来评估组间差异。采用加权多变量逻辑回归分析、亚组分析和交互作用检验来研究TyG指数与痛风的关联。

结果

最终参与者为11768人；其中5910人（50.32%）为女性，7784人（73.26%）年龄在18 - 60岁之间，5232人（69.63%）为白人，573人（5.12%）患有痛风。在调整所有协变量后，TyG指数与痛风呈正相关；TyG指数每增加一个单位，痛风的患病几率就会增加40%（优势比（OR），1.40；95%置信区间：1.82 - 2.66；p < 0.0001）。与最低三分位数组相比，TyG指数最高三分位数组的参与者患痛风的风险较高（优势比（OR），1.64；95%置信区间：1.06 - 2.54，p = 0.03）。交互作用检验表明，年龄、种族、婚姻状况、贫困收入比水平、教育程度、体重指数、吸烟状况、饮酒状况、高血压和糖尿病对TyG指数与痛风之间的这种关联没有显著影响（交互作用p > 0.05）。