Shuning Li, Wei Yang, Xuhui Fan, Jianfeng Dong, Jilun Liu
The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.
Lipids Health Dis. 2025 Apr 4;24(1):131. doi: 10.1186/s12944-025-02543-4.
Lipid Accumulation Product (LAP) is a biomarker associated with excessive lipid accumulation and various metabolic diseases. Despite the well-established link between oral and systemic health, the association between LAP and oral health remains largely unexplored.
Data from 7,124 participants aged over 18 years from the National Health and Nutrition Examination Survey (NHANES) between 2009 and 2014 were analyzed. Multivariate logistic regression models were applied to evaluate the independent association between LAP and self-reported oral health outcomes, adjusting for potential confounders.
There was a significant correlation between increasing LAP levels and deteriorating oral health status (β = 0.26, 95% CI: 0.20 to 0.32, P < 0.0001). Subgroup analyses revealed that the negative correlation between LAP and self-reported oral health outcomes was more pronounced in younger individuals and those with higher education levels. A non-linear relationship was identified, with oral health deteriorating significantly as LAP increased up to a threshold of 83, after which the relationship became non-significant.
This study demonstrates a robust association between LAP and self-reported oral health outcomes, suggesting that LAP could be a reliable indicator for assessing oral health status. The findings highlight the importance of targeted health interventions for populations with higher LAP indices to prevent oral health deterioration and potential systemic health issues.
脂质蓄积产物(LAP)是一种与脂质过度蓄积及多种代谢性疾病相关的生物标志物。尽管口腔健康与全身健康之间的联系已得到充分证实,但LAP与口腔健康之间的关联在很大程度上仍未得到探索。
分析了2009年至2014年间美国国家健康与营养检查调查(NHANES)中7124名18岁以上参与者的数据。应用多变量逻辑回归模型评估LAP与自我报告的口腔健康结果之间的独立关联,并对潜在混杂因素进行调整。
LAP水平升高与口腔健康状况恶化之间存在显著相关性(β = 0.26,95%置信区间:0.20至0.32,P < 0.0001)。亚组分析显示,LAP与自我报告的口腔健康结果之间的负相关在年轻人和受教育程度较高的人群中更为明显。确定了一种非线性关系,随着LAP升高至83的阈值,口腔健康显著恶化,此后这种关系变得不显著。
本研究表明LAP与自我报告的口腔健康结果之间存在密切关联,表明LAP可能是评估口腔健康状况的可靠指标。研究结果强调了针对LAP指数较高人群进行有针对性的健康干预以预防口腔健康恶化和潜在全身健康问题的重要性。