Division of Biomaterials, National Institutes for Food and Drug Control, Beijing, China.
Cardiothoracic Surgery Center, Fuwai Hospital Chinese Academy of Medical Sciences, Beijing, China.
Tissue Eng Part C Methods. 2024 Aug;30(8):353-363. doi: 10.1089/ten.TEC.2024.0144.
This study aims to determine the hemostatic effectivity and biocompatibility of a novel absorbable bone wax in comparison with a commercially available product. Eighteen small fat-tail sheep were used to simulate clinical surface bleeding of sternal injury. Hemostasis effectiveness, the degree of bone healing, micro-computed tomography, and histopathology were evaluated over a period after the application of the material to the surgically created wound. The absorbable bone wax used in the study stopped bleeding immediately and did not affect bone healing. The histopathological results also showed that there were no complications associated with the new material. The results showed that the new absorbable bone wax used in this study was effective and biocompatible.
本研究旨在比较一种新型可吸收骨蜡与市售产品的止血效果和生物相容性。18 只小肥尾羊被用来模拟胸骨损伤的临床表面出血。在应用材料于手术切口后，评估止血效果、骨愈合程度、微计算机断层扫描和组织病理学。研究中使用的可吸收骨蜡立即止血，且不影响骨愈合。组织病理学结果还表明，新型材料无相关并发症。结果表明，本研究中使用的新型可吸收骨蜡具有有效性和生物相容性。
