Yang Qing, Qu Ruize, Lu Siyi, Zhang Yi, Zhang Zhipeng, Fu Wei
Department of General Surgery, Peking University Third Hospital, Beijing China.
Cancer Center, Peking University Third Hospital, Beijing China.
Int J Med Sci. 2024 Jul 9;21(10):1824-1839. doi: 10.7150/ijms.97574. eCollection 2024.
Colorectal cancer is a heterogeneous disease which can be divided into proximal colon cancer, distal colon cancer and rectal cancer according to the anatomical location of the tumor. Each anatomical location of colorectal cancer exhibits distinct characteristics in terms of incidence, clinical manifestations, molecular phenotypes, treatment, and prognosis. Notably, proximal colon cancer differs significantly from cancers of other anatomical subsites. An increasing number of studies have highlighted the presence of unique tumor biological characteristics in proximal colon cancer. Gaining a deeper understanding of these characteristics will facilitate accurate diagnosis and treatment approaches.
结直肠癌是一种异质性疾病，可根据肿瘤的解剖位置分为近端结肠癌、远端结肠癌和直肠癌。结直肠癌的每个解剖位置在发病率、临床表现、分子表型、治疗和预后方面都表现出不同的特征。值得注意的是，近端结肠癌与其他解剖亚部位的癌症有显著差异。越来越多的研究强调了近端结肠癌中独特肿瘤生物学特征的存在。深入了解这些特征将有助于采取准确的诊断和治疗方法。
