Wang Li-Ying, Hu Si-Long, Yao Zhi-Feng, Xue Mei, Lu Zhen-Qi, Xiao-Ju Zhang, Ding Yan
Department of Nursing, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
School of Nursing, Fudan University, Shanghai, 200032, China.
Heliyon. 2024 Jul 4;10(14):e34106. doi: 10.1016/j.heliyon.2024.e34106. eCollection 2024 Jul 30.
An increasing number of research have applied neuroimaging techniques to explore the potential neurobiological mechanism of Cancer-related cognitive impairment (CRCI).
To explore the correlation between resting brain glucose metabolism and CRCI using F-FDG PET/CT in ovarian cancer (OC) patients.
From December 2021 to March 2022, 38 patients with OC were selected as the study group, and 38 healthy women of the same age (±1 year) who underwent routine physical examination using PET/CT were selected as the control group. Patients received further assessment with the Montreal Cognitive Assessment Scale (MoCA) and Perceived Deficit Questionnaire (PDQ). Independent sample -test and Spearman correlation were conducted for data analysis.
The resting brain glucose metabolism in the OC group was significantly lower than in the healthy controls. 60.52 % patients had neuropsychological impairment and retrospective memory were the most serious perceived cognitive impairments. The resting brain glucose metabolism in OC patients did not significantly correlate with neuropsychological performance but had significant positive correlation with subjective cognitive evaluation.
Resting glucose metabolism was low in OC patients and associated with subjective cognitive impairment but not objective neuropsychological test results. F-FDG PET/CT can be used to evaluate brain function in OC patients and provide reliable imaging indicators for early recognition of and intervention for changes in cognitive function.
越来越多的研究应用神经影像学技术来探索癌症相关认知障碍（CRCI）的潜在神经生物学机制。
利用F-FDG PET/CT探讨卵巢癌（OC）患者静息脑葡萄糖代谢与CRCI之间的相关性。
选取2021年12月至2022年3月期间38例OC患者作为研究组，选取38例年龄相仿（±1岁）且接受PET/CT常规体检的健康女性作为对照组。患者接受蒙特利尔认知评估量表（MoCA）和感知缺陷问卷（PDQ）的进一步评估。采用独立样本t检验和Spearman相关性分析进行数据分析。
OC组静息脑葡萄糖代谢显著低于健康对照组。60.52%的患者存在神经心理损害，其中回顾性记忆是最严重的感知认知损害。OC患者静息脑葡萄糖代谢与神经心理表现无显著相关性，但与主观认知评估呈显著正相关。
OC患者静息葡萄糖代谢较低，与主观认知损害相关，但与客观神经心理测试结果无关。F-FDG PET/CT可用于评估OC患者的脑功能，为早期识别和干预认知功能变化提供可靠的影像学指标。
