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干细胞移植后肠道移植相关微血管病的小肠并发症

Small Intestinal Complications of Intestinal Transplant-Associated Microangiopathy Post-stem Cell Transplantation.

作者信息

Kametaka Daisuke, Iwamuro Masaya, Tanaka Takehiro, Matsuoka Ken-Ichi, Otsuka Motoyuki

机构信息

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JPN.

Department of Pathology, Okayama University Hospital, Okayama, JPN.

出版信息

Cureus. 2024 Jul 8;16(7):e64111. doi: 10.7759/cureus.64111. eCollection 2024 Jul.

DOI:10.7759/cureus.64111
PMID:39114192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11305607/
Abstract

We present the case of a patient who underwent human leukocyte antigen-haploidentical transplantation for T-cell acute lymphoblastic leukemia. Seven weeks after transplantation, the patient developed intestinal transplant-associated microangiopathy (iTAM). Although the iTAM was resolved temporarily, it recurred. Video capsule enteroscopy revealed multiple erosions and shallow ulcers in the jejunum and ileum. To the best of our knowledge, this is the first report to present images of possible small intestinal lesions in iTAM. The small intestinal mucosal images presented herein may potentially aid in the management of similar patients.

摘要

我们报告了一例接受人类白细胞抗原单倍型相合移植治疗T细胞急性淋巴细胞白血病的患者。移植后7周，该患者发生了肠道移植相关微血管病（iTAM）。尽管iTAM暂时得到缓解，但又复发了。视频胶囊内镜检查显示空肠和回肠有多处糜烂和浅溃疡。据我们所知，这是第一份展示iTAM中可能存在的小肠病变图像的报告。本文展示的小肠黏膜图像可能有助于管理类似患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11305607/40842a3fd3e4/cureus-0016-00000064111-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11305607/865085a4e533/cureus-0016-00000064111-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11305607/634054436c56/cureus-0016-00000064111-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11305607/40842a3fd3e4/cureus-0016-00000064111-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11305607/865085a4e533/cureus-0016-00000064111-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11305607/634054436c56/cureus-0016-00000064111-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/091c/11305607/40842a3fd3e4/cureus-0016-00000064111-i03.jpg

相似文献

1
Small Intestinal Complications of Intestinal Transplant-Associated Microangiopathy Post-stem Cell Transplantation.干细胞移植后肠道移植相关微血管病的小肠并发症
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本文引用的文献

1
Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem cell transplantation.干细胞移植后肠道移植相关微血管病的内镜表现
BMC Gastroenterol. 2024 Apr 22;24(1):140. doi: 10.1186/s12876-024-03221-y.
2
Cell Therapy Transplant Canada (CTTC) Consensus-Based Guideline 2024 for Management and Treatment of Chronic Graft-Versus-Host Disease and Future Directions for Development.细胞治疗移植加拿大（CTTC）2024 年慢性移植物抗宿主病管理和治疗共识指南及未来发展方向。
Curr Oncol. 2024 Mar 8;31(3):1426-1444. doi: 10.3390/curroncol31030108.
3
Thrombotic Microangiopathy After Hematopoietic Stem Cell and Solid Organ Transplantation: A Review for Intensive Care Physicians.
造血干细胞和实体器官移植后的血栓性微血管病：重症监护医师的综述。
J Intensive Care Med. 2024 May;39(5):406-419. doi: 10.1177/08850666231200193. Epub 2023 Nov 21.
4
A prospective multi-institutional study of eculizumab to treat high-risk stem cell transplantation-associated TMA.一项前瞻性多机构研究，评估依库珠单抗治疗高危干细胞移植相关性 TMA。
Blood. 2024 Mar 21;143(12):1112-1123. doi: 10.1182/blood.2023022526.
5
Acute graft-versus-host disease.急性移植物抗宿主病。
Nat Rev Dis Primers. 2023 Jun 8;9(1):27. doi: 10.1038/s41572-023-00438-1.
6
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.协调移植相关性血栓性微血管病的诊断标准和预后评估定义：欧洲血液和骨髓移植学会、美国移植和细胞治疗学会、亚太血液和骨髓移植学会以及国际血液和骨髓移植研究中心的报告。
Transplant Cell Ther. 2023 Mar;29(3):151-163. doi: 10.1016/j.jtct.2022.11.015. Epub 2022 Nov 25.
7
Guideline development for prevention of transfusion-associated graft-versus-host disease: reduction of indications for irradiated blood components after prestorage leukodepletion of blood components.预防输血相关性移植物抗宿主病指南的制定：血液成分储存前白细胞去除后减少辐照血液成分的适应证。
Br J Haematol. 2021 Dec;195(5):681-688. doi: 10.1111/bjh.17822. Epub 2021 Sep 6.
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Transplant Cell Ther. 2021 Jul;27(7):540-544. doi: 10.1016/j.jtct.2021.03.012.
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Int J Hematol. 2019 Nov;110(5):529-532. doi: 10.1007/s12185-019-02750-7. Epub 2019 Oct 4.