Asaad Walaa, Utkina Marina, Shcherbakova Anastasia, Popov Sergey, Melnichenko Galina, Mokrysheva Natalia
Department of General, Molecular and Population Genetics, Endocrinology Research Centre, Moscow, Russia.
Front Endocrinol (Lausanne). 2024 Jul 24;15:1414223. doi: 10.3389/fendo.2024.1414223. eCollection 2024.
Pituitary neuroendocrine tumors (PitNETs) are common, most likely benign tumors with complex clinical characteristics related to hormone hypersecretion and/or growing sellar tumor mass. PitNET types are classified according to their expression of specific transcriptional factors (TFs) and hormone secretion levels. Some types show aggressive, invasive, and reoccurrence behavior. Current research is being conducted to understand the molecular mechanisms regulating these high-heterogeneous neoplasms originating from adenohypophysis, and single-cell RNA sequencing (scRNA-seq) technology is now playing an essential role in these studies due to its remarkable resolution at the single-cell level. This review describes recent studies on human PitNETs performed with scRNA-seq technology, highlighting the potential of this approach in revealing these tumor pathologies, behavior, and regulatory mechanisms.
垂体神经内分泌肿瘤（PitNETs）很常见，极有可能是良性肿瘤，具有与激素分泌过多和/或鞍区肿瘤肿块生长相关的复杂临床特征。PitNET类型根据其特定转录因子（TFs）的表达和激素分泌水平进行分类。某些类型表现出侵袭性、浸润性和复发性行为。目前正在开展研究以了解调节这些起源于腺垂体的高度异质性肿瘤的分子机制，而单细胞RNA测序（scRNA-seq）技术因其在单细胞水平上的卓越分辨率，目前在这些研究中发挥着至关重要的作用。本综述描述了最近使用scRNA-seq技术对人类PitNETs进行的研究，强调了这种方法在揭示这些肿瘤的病理、行为和调节机制方面的潜力。
