Cordingley Dean M, Marquez Izabella, Buchwald Serena C L, Zeiler Frederick A
Pan Am Clinic Foundation, Winnipeg, Canada.
Applied Health Sciences Program, Faculty of Graduate Studies, University of Manitoba, Winnipeg, Canada.
Neurotrauma Rep. 2024 Jul 29;5(1):708-720. doi: 10.1089/neur.2024.0062. eCollection 2024.
The purpose of this study was to identify the response of biomolecules and biomarkers that are associated with the central nervous system to aerobic exercise in human and pre-clinical models of concussion or mild traumatic brain injury (TBI), and to highlight the knowledge gaps in the literature. A systematic scoping review was conducted following a search of EMBASE, MEDLINE, SCOPUS, BIOSIS, and Cochrane Libraries performed on September 8, 2023 (from data base inception). The scoping review was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews. Duplicates were removed and article screening was performed using an online systematic review management system. The search resulted in a total of 2,449 articles being identified, with 14 articles meeting the inclusion/exclusion criteria and having their data extracted. One study was conducted in humans, while the remainder of identified studies utilized murine models. The current literature is limited and evaluated many different biomolecules and biomarkers with brain-derived neurotrophic factor being the most researched. Further studies on this topic are needed to better understand the biomarker response to exercise after concussion and mild TBI, especially in the human population.
本研究的目的是确定在人类以及脑震荡或轻度创伤性脑损伤（TBI）的临床前模型中，与中枢神经系统相关的生物分子和生物标志物对有氧运动的反应，并突出文献中的知识空白。在2023年9月8日（从数据库创建起）对EMBASE、MEDLINE、SCOPUS、BIOSIS和Cochrane图书馆进行检索之后，开展了一项系统性的范围综述。该范围综述按照系统评价和Meta分析的首选报告项目（PRISMA）扩展版中关于范围综述的要求进行报告。去除重复项，并使用在线系统评价管理系统进行文章筛选。检索总共识别出2449篇文章，其中14篇文章符合纳入/排除标准并提取了数据。1项研究在人类中开展，其余识别出的研究使用小鼠模型。当前的文献有限，且评估了许多不同的生物分子和生物标志物，其中脑源性神经营养因子是研究最多的。需要对此主题开展进一步研究，以更好地了解脑震荡和轻度TBI后生物标志物对运动的反应，尤其是在人类群体中。
