Cao Ning, Zhao Feiyan, Kwok Lai-Yu, Wang Huan, Sun Zhihong
Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Hohhot, 010018, China.
Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Hohhot, 010018, China.
Curr Res Food Sci. 2024 Jul 14;9:100810. doi: 10.1016/j.crfs.2024.100810. eCollection 2024.
Our meta-analysis aimed to assess the effectiveness of probiotics in weight loss and glucose and lipid metabolism in overweight or obese women. PubMed, EMBASE, Cochrane Library, and Web of Science were used from inception until March 2024 to identify randomized controlled trials (RCT's) literature. Finally, 11 RCTs were included. Following critical appraisal, a meta-analysis was conducted using the fixed effects model and the random effects model found that probiotic consumption significantly decreased waist circumference (WC) (SMD = -0.39 cm, 95% CI: -0.60, -0.18 cm, < 0.00001, I = 33%), insulin (SMD = -0.45 mcU/ml; 95% CI: -0.72, -0.18 mcU/ml; = 0.04, I = 40%) and low-density lipoprotein cholesterol (LDL-C) levels (SMD = -0.51 mmol/L; 95% CI: -0.92, -0.11 mmol/L; = 0.02, I = 75%) in overweight or obese women. Moreover, subgroup analyses revealed that the effects of probiotic supplementation were significantly influenced by the intervention duration and diet and/or exercise intervention. This meta-analysis suggested that probiotic supplementation has a moderate and statistically significant effect on weight loss and glucose and lipid metabolism in overweight and obese women.
我们的荟萃分析旨在评估益生菌对超重或肥胖女性体重减轻以及糖脂代谢的有效性。从数据库建立至2024年3月，我们检索了PubMed、EMBASE、Cochrane图书馆和科学网，以识别随机对照试验（RCT）文献。最终，纳入了11项RCT。经过严格评估后, 使用固定效应模型进行荟萃分析，随机效应模型发现，摄入益生菌可显著降低超重或肥胖女性的腰围（WC）（标准化均值差[SMD]= -0.39厘米，95%置信区间：-0.60，-0.18厘米，P<0.00001，I²=33%）、胰岛素（SMD = -0.45毫国际单位/毫升；95%置信区间：-0.72，-0.18毫国际单位/毫升；P = 0.04，I²=40%）和低密度脂蛋白胆固醇（LDL-C）水平（SMD = -0.51毫摩尔/升；95%置信区间：-0.92，-0.11毫摩尔/升；P = 0.02，I²=75%）。此外，亚组分析显示，补充益生菌的效果受干预持续时间以及饮食和/或运动干预的显著影响。该荟萃分析表明，补充益生菌对超重和肥胖女性的体重减轻以及糖脂代谢具有中度且具有统计学意义的影响。
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