Causal Association Between Type 2 Diabetes Mellitus and Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.

作者信息

Li Cong, Qian Haifeng, Feng Lina, Li Mingquan

机构信息

College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Department of Image Center, the Third Affiliated Clinical Hospital of the Changchun University of Chinese Medicine, Changchun, China.

出版信息

J Alzheimers Dis Rep. 2024 Jun 18;8(1):945-957. doi: 10.3233/ADR-240053. eCollection 2024.

DOI:10.3233/ADR-240053

PMID:39114544

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11305840/

Abstract

BACKGROUND

There is now increasing evidence that type 2 diabetes mellitus (T2DM) is associated with Alzheimer's disease (AD). However, it is unclear whether the two are causally related.

OBJECTIVE

To reveal the causal association between T2DM and AD, we performed a bidirectional Mendelian randomization (MR) analysis.

METHODS

Genetic instrumental variables were systematically screened, and inverse-variance weighting, MR-Egger regression, weighted median, simple mode, and weighted mode were applied to assess the pathogenic associations between the two diseases, and sensitivity analyses were used to further validate the robustness of the results.

RESULTS

The results of forward MR analysis with T2DM as the exposure were [OR = 0.998, 95% CI (0.975∼1.021), = 0.857], and the results of reverse MR analysis with AD as the exposure were [OR = 0.966, 95% CI (0.934∼0.999), = 0.043]. The results showed no significant association between T2DM and AD at the gene level ( < 0.025). Sensitivity analyses were consistent with the results of the main analysis, confirming the robustness of the study.