Blamey S L, Lowe G D, Bertina R M, Kluft C, Sue-Ling H M, Davies J A, Forbes C D
Thromb Haemost. 1985 Oct 30;54(3):622-5.
Activated protein C is a potent inhibitor of coagulation, and familial protein C deficiency has been associated with recurrent venous thrombosis. We have investigated protein C antigen levels in patients undergoing major elective abdominal surgery, to determine their relationships to postoperative deep vein thrombosis (DVT), malignancy, and preoperative treatment with intramuscular or oral stanozolol. Preoperative and postoperative protein C levels were not significantly different in patients with and without DVT (detected by 125I-fibrinogen leg scans), nor in patients with and without malignancy. In a placebo group (n = 26), a significant fall in protein C was maximal on the first postoperative day and persisted for 7 days. In a group given intramuscular stanozolol, 50 mg on the preoperative day (n = 23) stanozolol shortened the duration of the postoperative fall in protein C, but did not prevent DVT. In a group given oral stanozolol, 10 mg/day for 2 weeks before and 1 week after operation (n = 11), stanozolol significantly increased protein C levels prior to surgery, hence maintaining protein C at pretreatment levels after surgery. The effect of this regimen on the incidence of DVT is under study.
活化蛋白C是一种强效的凝血抑制剂，家族性蛋白C缺乏与复发性静脉血栓形成有关。我们研究了接受大型择期腹部手术患者的蛋白C抗原水平，以确定其与术后深静脉血栓形成（DVT）、恶性肿瘤以及术前肌肉注射或口服司坦唑醇治疗之间的关系。有或无DVT（通过125I-纤维蛋白原腿部扫描检测）的患者，以及有或无恶性肿瘤的患者，术前和术后的蛋白C水平均无显著差异。在一个安慰剂组（n = 26）中，术后第一天蛋白C显著下降至最低水平，并持续7天。在术前一天给予50 mg肌肉注射司坦唑醇的组（n = 23）中，司坦唑醇缩短了术后蛋白C下降的持续时间，但并未预防DVT。在术前2周和术后1周每天给予10 mg口服司坦唑醇的组（n = 11）中，司坦唑醇显著提高了手术前的蛋白C水平，从而使术后蛋白C维持在术前水平。该方案对DVT发生率的影响正在研究中。
