Yuen E H, Goold R D, Wilson B J
Steroids. 1985 Jan;45(1):53-72. doi: 10.1016/0039-128x(85)90065-0.
Norethynodrel proved to have moderately potent effects on hepatic function in female rats. It causes (a) loss of body mass, (b) increase in the relative liver mass, (c) rise in the protein content of liver, (d) increase in the cytochrome P-450 level, (e) reduction in the length of pentobarbital-induced sleep, and (f) increase in the rate of biotransformation of (i) aniline and (ii) aminopyrine. In contrast, ethynyl estradiol was shown to have little or no effect as judged by the same criteria, but, like norethynodrel, progesterone and estradiol, caused loss of body mass.
炔诺酮已被证明对雌性大鼠的肝功能有中等强度的影响。它会导致：(a)体重减轻；(b)肝脏相对重量增加；(c)肝脏蛋白质含量升高；(d)细胞色素P - 450水平增加；(e)戊巴比妥诱导的睡眠时间缩短；以及(f)(i)苯胺和(ii)氨基比林的生物转化速率增加。相比之下，根据相同标准判断，乙炔雌二醇几乎没有影响，但与炔诺酮、孕酮和雌二醇一样，会导致体重减轻。
