Department of Chemistry, Fudan University, 220 Handan Road, 200433 Shanghai, China.
ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, 200031 Shanghai, China.
J Am Chem Soc. 2024 Aug 21;146(33):22869-22873. doi: 10.1021/jacs.4c05959. Epub 2024 Aug 8.
Tubular structures exist broadly in biological systems and exhibit important functions including mediating cellular communications. The construction of artificial analogues in living cells would provide a new strategy for chemotherapy. In this report, a kind of supramolecular channel has been constructed within intercellular gaps by mimicking the assembly process and structure of natural gap junctional channels, which consist of hydrophobic tubular modules located in the adjacent cell membranes and hydrophilic modules within the extracellular space. The assembly of the channels was driven by electrostatic interactions. The channels could inhibit tumor cell invasion by preventing cell migration.
管状结构广泛存在于生物系统中，具有重要的功能，包括介导细胞通讯。在活细胞中构建人工类似物将为化疗提供新的策略。在本报告中，通过模拟天然缝隙连接通道的组装过程和结构，在细胞间隙内构建了一种超分子通道，该通道由位于相邻细胞膜中的疏水性管状模块和细胞外空间中的亲水性模块组成。通道的组装是由静电相互作用驱动的。该通道可以通过阻止细胞迁移来抑制肿瘤细胞侵袭。
